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  4. Recombinant Human Rho-guanine nucleotide exchange factor (RGNEF), partial

Recombinant Human Rho-guanine nucleotide exchange factor (RGNEF), partial

  • 中文名称：
    Recombinant Human Rho-guanine nucleotide exchange factor(RGNEF) ,partial
  • 货号：
    CSB-YP850782HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Rho-guanine nucleotide exchange factor(RGNEF) ,partial
  • 货号：
    CSB-EP850782HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Rho-guanine nucleotide exchange factor(RGNEF) ,partial
  • 货号：
    CSB-EP850782HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Rho-guanine nucleotide exchange factor(RGNEF) ,partial
  • 货号：
    CSB-BP850782HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Rho-guanine nucleotide exchange factor(RGNEF) ,partial
  • 货号：
    CSB-MP850782HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ARHGEF28
  • Uniprot No.：
    Q8N1W1
  • 别名：
    ARHGEF28; KIAA1998; RGNEF; Rho guanine nucleotide exchange factor 28; 190 kDa guanine nucleotide exchange factor; p190-RhoGEF; p190RhoGEF; Rho guanine nucleotide exchange factor
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis.
  • 基因功能参考文献：
    1. results show that Rgnef functions as an effector of Galpha13 signaling and that this linkage may mediate FAK activation in DLD-1 colon carcinoma cells PMID: 25922072
    2. This study showed that ARHGEF28 gene exon 6/intron 6 junction mutations in Chinese amyotrophic lateral sclerosis cohort. PMID: 24712971
    3. Study identified a heterozygous mutation in amyotrophic lateral sclerosis patients that is predicted to generate a premature truncated ARHGEF28 gene product. There were extensive regions of homozygosity in the ARHGEF28 gene in two familial ALS patients. PMID: 23286752
    4. This study demonistrated that RGNEF-immunoreactive neuronal cytoplasmic inclusions (NCIs) can co-localize with TDP-43, FUS/TLS and p62 within spinal motor neurons. PMID: 22941224
    5. Studies identify Rgnef as a novel regulator of colon carcinoma motility and invasion, and they show that a Rgnef-FAK linkage promotes colon carcinoma progression in vivo. PMID: 21224360
    6. RGNEF is a human homologue of p190RhoGEF, and its RNA is expressed in both brain and spinal cord PMID: 19488899

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  • 亚细胞定位：
    Cytoplasm. Cell membrane.
  • 数据库链接：

    HGNC: 30322

    OMIM: 612790

    KEGG: hsa:64283

    STRING: 9606.ENSP00000411459

    UniGene: Hs.482521

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