Recombinant Human Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (PDE6H)

中文名称：

人PDE6H重组蛋白
货号：

CSB-YP617840HU
规格：
来源：

Yeast
其他：

中文名称：

人PDE6H重组蛋白
货号：

CSB-EP617840HU
规格：
来源：

E.coli
其他：

中文名称：

人PDE6H重组蛋白
货号：

CSB-EP617840HU-B
规格：
来源：

E.coli
共轭：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名称：

人PDE6H重组蛋白
货号：

CSB-BP617840HU
规格：
来源：

Baculovirus
其他：

中文名称：

人PDE6H重组蛋白
货号：

CSB-MP617840HU
规格：
来源：

Mammalian cell
其他：

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纯度：

>85% (SDS-PAGE)
基因名：

PDE6H
Uniprot No.：

Q13956
别名：

5''-cyclic phosphodiesterase subunit gamma; CNCG_HUMAN; GMP-PDE gamma; Pde6h; Retinal cone rhodopsin-sensitive cGMP 3''
种属：

Homo sapiens (Human)
蛋白长度：

full length protein
表达区域：

1-83
氨基酸序列

MSDNTTLPAP ASNQGPTTPR KGPPKFKQRQ TRQFKSKPPK KGVKGFGDDI PGMEGLGTDI TVICPWEAFS HLELHELAQF GII
蛋白标签：

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
产品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
复溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
储存条件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保质期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
货期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事项：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

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功能：

Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.
基因功能参考文献：
1. These findings add PDE6H to the set of genes involved in autosomal-recessive cone disorders and demonstrate the importance of the inhibitory gamma subunit in cone phototransduction PMID: 22901948
2. Our results indicate that mutations in the PDE6H gene are not common, because only 1 of 240 patients with cone dystrophy showed a single nucleotide substitution in the 5' UTR of PDE6H mRNA PMID: 15629837
相关疾病：

Cone dystrophy, retinal 3A (RCD3A)
蛋白家族：

Rod/cone cGMP-PDE gamma subunit family
数据库链接：

HGNC: 8790

OMIM: 601190

KEGG: hsa:5149

STRING: 9606.ENSP00000266395

UniGene: Hs.54471

Recombinant Human Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (PDE6H)

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