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  4. Recombinant Human Regulating synaptic membrane exocytosis protein 1 (RIMS1), partial

Recombinant Human Regulating synaptic membrane exocytosis protein 1 (RIMS1), partial

  • 中文名称：
    人RIMS1重组蛋白
  • 货号：
    CSB-YP768211HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人RIMS1重组蛋白
  • 货号：
    CSB-EP768211HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人RIMS1重组蛋白
  • 货号：
    CSB-EP768211HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人RIMS1重组蛋白
  • 货号：
    CSB-BP768211HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人RIMS1重组蛋白
  • 货号：
    CSB-MP768211HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    RIMS1
  • Uniprot No.：
    Q86UR5
  • 别名：
    RIMS1; KIAA0340; RAB3IP2; RIM1; Nbla00761; Regulating synaptic membrane exocytosis protein 1; Rab-3-interacting molecule 1; RIM 1; Rab-3-interacting protein 2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Rab effector involved in exocytosis. May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity. Plays a role in dendrite formation by melanocytes.
  • 基因功能参考文献：
    1. This is the first reported case of bilateral cystoid macular edema in association with the RIM1 mutation. Overall, our findings were more consistent with a phenotype of retinitis pigmentosa. PMID: 27176872
    2. The study identified a region on chromosome 6 comprising the genes SMAP1, B3GAT2, and RIMS1 as novel susceptibility locus for pediatric venous thromboembolism. PMID: 28011674
    3. Electrophysiological characterization of VDCC currents revealed that the suppressive effect of RIM2alpha on voltage-dependent inactivation (VDI) was stronger than that of RIM1alpha for the CaV2.1 variant containing the region encoded by exons 44 and 47. PMID: 28377503
    4. Here, we report that, like Rab3A, RIM and Munc13 are present in human sperm and that they play a functional role in acrosomal exocytosis before the acrosomal calcium efflux PMID: 22248876
    5. a novel functional coupling between RIM1 and the L-type Ca(V) channels via the Ca(V)beta auxiliary subunit that contribute to determine insulin secretion. PMID: 21402706
    6. Rim1 modulates direct G-protein regulation of Ca(v)2.2 channels. PMID: 21331761
    7. Rim1 is a component of the presynaptic active zone and modulator of exocytosis and binds 14-3-3 through its N terminus PMID: 12871946
    8. Even though the absence of pathogenic mutations suggests that RIM1 is notinvolved in autosomal recessive retinitis pigmentosa. PMID: 15746564
    9. A possible role for RIMS1 in the enhancement of cognitive function at least in this kindred is suggested. PMID: 17237123

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  • 相关疾病：
    Cone-rod dystrophy 7 (CORD7)
  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein. Cell junction, synapse. Cell junction, synapse, presynaptic cell membrane; Peripheral membrane protein.
  • 组织特异性：
    Expressed in melanocytes. Detected in brain and retina.
  • 数据库链接：

    HGNC: 17282

    OMIM: 603649

    KEGG: hsa:22999

    STRING: 9606.ENSP00000428417

    UniGene: Hs.485729

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