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  4. Recombinant Human Rap guanine nucleotide exchange factor 6 (RAPGEF6), partial

Recombinant Human Rap guanine nucleotide exchange factor 6 (RAPGEF6), partial

  • 中文名称：
    人RAPGEF6重组蛋白
  • 货号：
    CSB-YP848419HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人RAPGEF6重组蛋白
  • 货号：
    CSB-EP848419HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人RAPGEF6重组蛋白
  • 货号：
    CSB-EP848419HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人RAPGEF6重组蛋白
  • 货号：
    CSB-BP848419HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人RAPGEF6重组蛋白
  • 货号：
    CSB-MP848419HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    RAPGEF6
  • Uniprot No.：
    Q8TEU7
  • 别名：
    DKFZp667N084; DKFZp686I15116 ; KIA001LB; PDZ domain containing guanine nucleotide exchange factor (GEF) 2; PDZ domain containing guanine nucleotide exchange factor 2; PDZ domain containing guanine nucleotide exchange factor I; PDZ domain-containing guanine nucleotide exchange factor 2; PDZ GEF 2; PDZ GEF2; PDZ-GEF2; PDZGEF 2; PDZGEF2; RA GEF 2; RA GEF2; RA-GEF-2; RAGEF 2; Rap guanine nucleotide exchange factor (GEF) 6 ; Rap guanine nucleotide exchange factor 2; Rap guanine nucleotide exchange factor 6; RAPGEF6; RPGF6_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP.
  • 基因功能参考文献：
    1. local accumulation of PDZGEF at the apical membrane during establishment of epithelial polarity is mediated by electrostatic interactions between positively charged side chains in the PDZ domain and negatively charged phosphatidic acid. PMID: 24858808
    2. BAG3 overexpression increases cell adhesion in Cos7 cells, but not in PDZGEF2 gene knockdown cells indicating that PDZGEF2 is a critical partner for BAG3 in regulating cell adhesion PMID: 20800573
    3. the second PDZ domain from human phosphatase hPTP1E in complex with a C-terminal peptide from the guanine nucleotide exchange factor RA-GEF-2 has been determined PMID: 12095257
    4. haplotypes underlying the SPEC2/PDZ-GEF2/acyl-CoA synthetase long-chain family member 6 region are associated with schizophrenia PMID: 17030554
    5. PDZ-GEF2 plays a critical role in the maturation of adherens junctions. PMID: 18585005
    6. When males and females were analysed separately, SNP4 (rs31251) in PDZ-GEF2 is associated with schizophrenia in females in Han Chinese. PMID: 18718982
    7. JAM-A dimerization facilitates formation of a complex with Afadin and PDZ-GEF2 that activates Rap1A, which regulates beta1 integrin levels and cell migration. PMID: 19176753
    8. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 18804346

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  • 亚细胞定位：
    Cytoplasm. Cell membrane. Note=Upon binding to M-Ras, it translocates to the plasma membrane.
  • 组织特异性：
    Isoform 3 has highest expression levels in the brain, heart, liver, lung and placenta and is barely detectable in skeletal muscle, kidney and pancreas.
  • 数据库链接：

    HGNC: 20655

    OMIM: 610499

    KEGG: hsa:51735

    STRING: 9606.ENSP00000296859

    UniGene: Hs.483329

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