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  4. Recombinant Human Ral guanine nucleotide dissociation stimulator (RALGDS), partial

Recombinant Human Ral guanine nucleotide dissociation stimulator (RALGDS), partial

  • 中文名称：
    人RALGDS重组蛋白
  • 货号：
    CSB-YP019299HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人RALGDS重组蛋白
  • 货号：
    CSB-EP019299HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人RALGDS重组蛋白
  • 货号：
    CSB-EP019299HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人RALGDS重组蛋白
  • 货号：
    CSB-BP019299HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人RALGDS重组蛋白
  • 货号：
    CSB-MP019299HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    RALGDS
  • Uniprot No.：
    Q12967
  • 别名：
    RALGDS; KIAA1308; RGFRal guanine nucleotide dissociation stimulator; RalGDS; Ral guanine nucleotide exchange factor; RalGEF
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap.
  • 基因功能参考文献：
    1. Investigated is the role that electrostatic field differences caused by the charge reversal mutation Rap1A K31E play in determining the binding specificity of RalGDS to Rap1A versus Ras. PMID: 22738401
    2. involved in regulation of choline kinase activity by Ras proteins PMID: 11840339
    3. identified Ral-GDS as a beta-arrestin-binding protein by yeast two-hybrid screening and co-immunoprecipitation from human polymorphonuclear neutrophilic leukocytes PMID: 12105416
    4. RALGDS has a role in attenuating p53-independent DNA damage G2 checkpoint PMID: 15208305
    5. Merlin can function as a tumor suppressor by inhibiting the RalGDS-mediated oncogenic signals. PMID: 16007223
    6. results of screening suggest that RALGDS is not mutationally altered in cutaneous melanoma PMID: 17992125
    7. overexpression of RalGDS promotes exocytosis of Weibel-Palade bodies from endothelial cells PMID: 18417737
    8. RalGDS and RalA act downstream of Rheb and that RalA activation is a crucial step in nutrient-induced mTORC1 activation PMID: 18948269

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 数据库链接：

    HGNC: 9842

    OMIM: 601619

    KEGG: hsa:5900

    STRING: 9606.ENSP00000361120

    UniGene: Hs.106185

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