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  4. Recombinant Human RNA polymerase-associated protein CTR9 homolog (CTR9), partial

Recombinant Human RNA polymerase-associated protein CTR9 homolog (CTR9), partial

  • 中文名称：
    Recombinant Human RNA polymerase-associated protein CTR9 homolog(CTR9) ,partial
  • 货号：
    CSB-YP750854HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human RNA polymerase-associated protein CTR9 homolog(CTR9) ,partial
  • 货号：
    CSB-EP750854HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human RNA polymerase-associated protein CTR9 homolog(CTR9) ,partial
  • 货号：
    CSB-EP750854HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human RNA polymerase-associated protein CTR9 homolog(CTR9) ,partial
  • 货号：
    CSB-BP750854HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human RNA polymerase-associated protein CTR9 homolog(CTR9) ,partial
  • 货号：
    CSB-MP750854HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CTR9
  • Uniprot No.：
    Q6PD62
  • 别名：
    Ctr 9; CTR9; Ctr9 Paf1/RNA polymerase II complex component; homolog; CTR9; Paf1/RNA polymerase II complex componen; CTR9; S. cerevisiae; homolog of; CTR9_HUMAN; KIAA0155; p150; p150(TSP); p150TSP.; Paf1/RNA polymerase II complex component homolog Ctr9; RNA polymerase associated protein CTR9 homolog; RNA polymerase-associated protein CTR9 homolog; SH2 binding phosphoprotein; SH2 domain binding protein 1 (tetratricopeptide repeat containing) ; SH2 domain binding protein 1; SH2 domain-binding protein 1; SH2-binding phosphoprotein of 150 kDa; SH2BP1; Tetratricopeptide repeat-containing; Tetratricopeptide-containing SH2-binding phosphoprotein 150-KD; TPR containing; SH2-binding phosphoprotein of 150 kDa; TSBP
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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靶点详情

  • 功能：
    Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3) and dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of the SET1 complex. Involved in transcriptional regulation of IL6-responsive genes and in JAK-STAT pathway; may regulate DNA-association of STAT3.
  • 基因功能参考文献：
    1. A novel CTR9 germline variant, located in a consensus splice acceptor site, was found to segregate with Wilms tumor in the family. PMID: 29292210
    2. Our data demonstrated that Ctr9, independent of other PAFc subunits, controls ERalpha-target gene expression by regulating global chromatin occupancies of ERalpha and RNAPII. PMID: 27829357
    3. Ctr9, a key subunit of hPAFc, is a central regulator of estrogen signaling that drives ERalpha(+) breast tumorigenesis PMID: 26494790
    4. Ctr9, formerly identified as a nuclei protein, interacts with the dopamine transporter in the cytoplasmic compartment. PMID: 26048990
    5. CTR9 is a PAF1 complex gene whose germline mutations predispose to Wilms tumour PMID: 25099282
    6. CTR9, a component of PAF complex, controls elongation block at the c-Fos locus via signal-dependent regulation of chromatin-bound NELF dissociation. PMID: 23593388
    7. MLL interacts directly with the polymerase associated factor complex (PAFc) via Paf1 and CTR9. PAFc augments MLL and MLL-AF9 mediated transcriptional activation of Hoxa9 and their interaction is essential for leukemogenesis. PMID: 20541477
    8. CTR9 participates in the transcription of IL-6-responsive genes through the regulation of DNA association of STAT3 and modification of histone methylation PMID: 17911113

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  • 亚细胞定位：
    Nucleus speckle.
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 16850

    OMIM: 609366

    KEGG: hsa:9646

    STRING: 9606.ENSP00000355013

    UniGene: Hs.725151

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