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  4. Recombinant Human Putative Polycomb group protein ASXL3 (ASXL3), partial

Recombinant Human Putative Polycomb group protein ASXL3 (ASXL3), partial

  • 中文名称：
    Recombinant Human Putative Polycomb group protein ASXL3(ASXL3) ,partial
  • 货号：
    CSB-YP863178HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Putative Polycomb group protein ASXL3(ASXL3) ,partial
  • 货号：
    CSB-EP863178HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Putative Polycomb group protein ASXL3(ASXL3) ,partial
  • 货号：
    CSB-EP863178HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Putative Polycomb group protein ASXL3(ASXL3) ,partial
  • 货号：
    CSB-BP863178HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Putative Polycomb group protein ASXL3(ASXL3) ,partial
  • 货号：
    CSB-MP863178HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ASXL3
  • Uniprot No.：
    Q9C0F0
  • 别名：
    ASXL3; KIAA1713; Putative Polycomb group protein ASXL3; Additional sex combs-like protein 3
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility.
  • 基因功能参考文献：
    1. A second mutation cluster region within ASXL3 in older patients with Bainbridge-Ropers syndrome expands the phenotypic spectrum of the disorder and highlights its high frequency. PMID: 28100473
    2. Data indicate that ASXL3 was markedly upregulated in lung iPSCs (Lu-iPSC) and small cell lung cancer (SCLC) lines and clinical specimens. PMID: 28935813
    3. Our findings suggest that the expression of the truncated ASXL3 protein, including ASXN and ASXH domains, give rise to Bainbridge-Ropers syndrome , which is distinct from but overlaps with Bohring-Opitz syndrome PMID: 27075689
    4. data suggest that ASXL3 is another corepressor of LXRalpha, promoting to the regulation of lipid homeostasis PMID: 25450400
    5. Loss-of-function variants in ASXL3 identified as causal for Bainbridge-Ropers syndrome. PMID: 27901041
    6. De novo dominant ASXL3 mutations alter H2A deubiquitination and transcription in Bainbridge-Ropers syndrome. PMID: 26647312
    7. in contrast with ASXL1 and ASXL2 mutations, ASXL3 mutations were rare events within t(8;21)-AML patients. PMID: 25856206

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  • 相关疾病：
    Bainbridge-Ropers syndrome (BRPS)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Asx family
  • 组织特异性：
    Expressed in pancreatic islets, testis, neuroblastoma, head and neck tumor.
  • 数据库链接：

    HGNC: 29357

    OMIM: 615115

    KEGG: hsa:80816

    STRING: 9606.ENSP00000269197

    UniGene: Hs.464876

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