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  4. Recombinant Human Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP)

Recombinant Human Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP)

  • 中文名称：
    Recombinant Human Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial(CLPP)
  • 货号：
    CSB-YP618094HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial(CLPP)
  • 货号：
    CSB-EP618094HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial(CLPP)
  • 货号：
    CSB-EP618094HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial(CLPP)
  • 货号：
    CSB-BP618094HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial(CLPP)
  • 货号：
    CSB-MP618094HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CLPP
  • Uniprot No.：
    Q16740
  • 别名：
    ATP dependent protease ClpAP (E coli) proteolytic subunit; ATP dependent protease ClpAP proteolytic subunit; ATP dependent protease ClpAP proteolytic subunit human; ATP dependent proteolytic subunit homolog (E coli); ATP dependent proteolytic subunit homolog; Caseinolytic peptidase ATP dependent proteolytic subunit homolog; Caseinolytic protease ATP dependent proteolytic subunit E coli; clpP; ClpP caseinolytic peptidase ATP dependent proteolytic subunit; ClpP caseinolytic peptidase ATP dependent proteolytic subunit homolog; CLPP_HUMAN; Endopeptidase Clp; mitochondrial; Putative ATP dependent Clp protease proteolytic subunit mitochondrial; Putative ATP dependent Clp protease proteolytic subunit; Putative ATP-dependent Clp protease proteolytic subunit
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    57-277
  • 氨基酸序列
    PLIP IVVEQTGRGE RAYDIYSRLL RERIVCVMGP IDDSVASLVI AQLLFLQSES NKKPIHMYIN SPGGVVTAGL AIYDTMQYIL NPICTWCVGQ AASMGSLLLA AGTPGMRHSL PNSRIMIHQP SGGARGQATD IAIQAEEIMK LKKQLYNIYA KHTKQSLQVI ESAMERDRYM SPMEAQEFGI LDKVLVHPPQ DGEDEPTLVQ KEPVEAAPAA EPVPAST
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

相关产品

CLPP antibodies

靶点详情

  • 功能：
    Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates. Cleaves PINK1 in the mitochondrion.
  • 基因功能参考文献：
    1. Autophagy compensates impaired energy metabolism in CLPXP-deficient Podospora anserina strains and extends healthspan. PMID: 28449241
    2. we demonstrate that a strong mitochondrial cardiomyopathy and diminished respiration due to DARS2 deficiency can be alleviated by the loss of CLPP, leading to an increased de novo synthesis of individual OXPHOS subunits. PMID: 27154400
    3. ere we present eight families affected by Perrault syndrome. In five families we identified novel or previously reported variants in HSD17B4, LARS2, CLPP and C10orf2 PMID: 26970254
    4. Data suggest that tumors exploit ClpXP-directed proteostasis to maintain mitochondrial bioenergetics, buffer oxidative stress, and enable metastatic competence. PMID: 27389535
    5. Data indicate endopeptidase Clp (ClpP) mutation identified in two patients with Perrault syndrome type 3 in a Turkish family. PMID: 27087618
    6. ClpP proteases from E. coli, S. aureus, and human mitochondria exhibit preferences for certain amino acids in the P1, P2, and P3 positions . PMID: 26606371
    7. Optical trapping to assay single-molecule ClpXP unfolding and translocation of substrates consisting of domains with varying stabilities and sequences; find that ClpXP unfolds most domains by a single pathway, with kinetics that depend on the native fold and structural stability. PMID: 25083874
    8. Deletion of PaClpP, leads to an unexpected healthy phenotype and increased lifespan of the fungal ageing model organism Podospora anserina and This phenotype can be reverted by expression of human ClpP. PMID: 23360988
    9. Perrault syndrome is caused by recessive mutations in CLPP. PMID: 23541340
    10. the N-terminal peptide of ClpP is a structural component of the substrate translocation channel and may play an important functional role as well PMID: 15522782
    11. hClpX can regulate the appearance of hClpP peptidase activity in mitochondria and might affect the nature of the degradation products released during ATP-dependent proteolytic cycles PMID: 16115876
    12. We propose that decreased levels of mitochondrial proteases Lon and ClpP may allow heat shock protein 60 substrate proteins to go through more folding attempts PMID: 18378094

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  • 相关疾病：
    Perrault syndrome 3 (PRLTS3)
  • 亚细胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    Peptidase S14 family
  • 组织特异性：
    Detected in liver (at protein level). Predominantly expressed in skeletal muscle. Intermediate levels in heart, liver and pancreas. Low in brain, placenta, lung and kidney.
  • 数据库链接：

    HGNC: 2084

    OMIM: 601119

    KEGG: hsa:8192

    STRING: 9606.ENSP00000245816

    UniGene: Hs.515092

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