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  4. Recombinant Human Protocadherin Fat 1 (FAT1), partial

Recombinant Human Protocadherin Fat 1 (FAT1), partial

In Stock
  • 中文名称：
    人FAT1重组蛋白
  • 货号：
    CSB-EP614532HU
  • 规格：
    ￥1836
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    FAT1
  • Uniprot No.：
    Q14517
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 来源：
    E.coli
  • 分子量：
    49.2 kDa
  • 表达区域：
    4203-4588aa
  • 氨基酸序列
    RKMISRKKKHQAEPKDKHLGPATAFLQRPYFDSKLNKNIYSDIPPQVPVRPISYTPSIPSDSRNNLDRNSFEGSAIPEHPEFSTFNPESVHGHRKAVAVCSVAPNLPPPPPSNSPSDSDSIQKPSWDFDYDTKVVDLDPCLSKKPLEEKPSQPYSARESLSEVQSLSSFQSESCDDNGYHWDTSDWMPSVPLPDIQEFPNYEVIDEQTPLYSADPNAIDTDYYPGGYDIESDFPPPPEDFPAADELPPLPPEFSNQFESIHPPRDMPAAGSLGSSSRNRQRFNLNQYLPNFYPLDMSEPQTKGTGENSTCREPHAPYPPGYQRHFEAPAVESMPMSVYASTASCSDVSACCEVESEVMMSDYESGDDGHFEEVTIPPLDSQQHTEV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

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FAT1 antibodies

FAT1 Proteins

靶点详情

  • 功能：
    Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact.
  • 基因功能参考文献：
    1. Fat1 functional loss results in YAP1 activation and is associated with human malignancies. PMID: 29985391
    2. Study showed that FAT1 exhibits a high frequency of mutations and a downregulated expression in esophageal squamous cell carcinoma (ESCC) leading to cell migration and invasion by affecting the cellular mechanical properties of ESCC cells. PMID: 29565465
    3. FAT1 has a novel regulatory effect on EMT/stemness markers both via or independent of HIF-1alpha. The functional relevance of this study was corroborated by significant reduction in the number of soft-agar colonies formed in hypoxic-siFAT1 treated U87MG cells. PMID: 28994107
    4. FAT1 mutational status is a strong independent prognostic factor in patients with HPV-negative head and neck squamous cell carcinoma; FAT1 mutation was significantly associated with better overall survival PMID: 26876381
    5. Disruption of MAPK/ERK pathway by FAT1 contributes the epithelial mesenchymal transformation in esophageal squamous cell carcinomas. PMID: 28366557
    6. Loss of function mutations in FAT1 and CASP8 prevent cell adhesion and promote cell migration and proliferation in oral squamous cell carcinoma cell lines. PMID: 27693639
    7. We identified recurrent mutations in the novel penile cancer tumor suppressor genes CSN1(GPS1) and FAT1 PMID: 27325650
    8. FAT1 and mAb198.3 may offer new therapeutic opportunities for CRC. PMID: 27328312
    9. Data show that the two N-terminal SH3 domains of SH3 domain containing ring finger 1 (SH3RF1) protein interact with FAT1 protein. PMID: 28129444
    10. At the molecular level, under hypoxia the FAT1 depletion-associated reduction in HIF1alpha was due to compromised EGFR-Akt signaling as well as increased VHL-dependent proteasomal degradation of HIF1alpha. PMID: 27536856
    11. Low FAT1 expression was associated with poor prognosis in children with medulloblastoma. Furthermore, FAT1 may act on Wnt signaling pathway to exert its antitumor effect PMID: 27834469
    12. Recessive mutations in FAT1 cause a distinct renal disease entity in four families with a combination of steroid-resistance nephrotic syndrome, tubular ectasia, haematuria and facultative neurological involvement. PMID: 26905694
    13. that loss of FAT1 and beta-catenin are associated with breast cancer progression, aggressive behavior, and poor prognosis PMID: 26721716
    14. FAT1 protein acts upstream of Hippo signalling through TAZ protein to regulate neuronal differentiation. PMID: 26104008
    15. Fat1 is released from pancreatic cancer cells in its soluble form by ADAM10 mediated ectodomain shedding PMID: 24625754
    16. our data suggest that defective FAT1 is associated with an FSHD-like phenotype. PMID: 25615407
    17. FAT1 is expressed at lower levels in muscles that are affected at early stages of facioscapulohumeral muscular dystrophy progression. PMID: 26018399
    18. Analysis revealed an aberrant expression of FAT1 predominantly in mature BCP-ALL and thymic T-ALL and a high rate of FAT1 mutations. PMID: 24972153
    19. FJX1 does not influence the levels of FAT1 ectodomain phosphorylation. PMID: 25150169
    20. FAT1 expression in HCC is regulated via promotor methylation. PMID: 24590895
    21. Fat1 may therefore provide a new marker of MRD for patients with ALL lacking known genomic aberrations or within a multiplex approach to MRD detection. PMID: 23433465
    22. This work establishes S1-processing as a clear functional prerequisite for ectodomain shedding of FAT1 with general implications for the shedding of other transmembrane receptors. PMID: 24560745
    23. frequency of FAT1-mutated cases was significantly higher in drug resistant chronic lymphocytic leukemia than in unselected chronic lymphocytic leukemia PMID: 24550227
    24. There is a mechanism to regulate death receptor-mediated apoptosis via an interaction between FAT1 and procaspase-8. PMID: 24442637
    25. this study identifies a novel signaling mechanism mediated by FAT1 in regulating the activity of PDCD4 in gliomas. PMID: 22986533
    26. Our study identifies FAT1 as a critical determinant of muscle form, misregulation of which associates with facioscapulohumeral dystrophy . PMID: 23785297
    27. Taken together, these data strongly point to FAT1 as a tumor suppressor gene driving loss of chromosome 4q35, a prevalent region of deletion in cancer PMID: 23354438
    28. FAT1 suppression in activated hepatic stellate cells caused a downregulation of NFkappaB activity PMID: 22959770
    29. Lipid accumulation in myotubes derived from obese type 2 diabetic patients arises from abnormal FAT/CD36 cycling. PMID: 22194967
    30. data presented demonstrate that Fat1 expression in preB-ALL has a role in the emergence of relapse and could provide a suitable therapeutic target in high-risk preB-ALL PMID: 22116550
    31. In vitro localization studies of FAT1 showed that melanoma cells display high levels of cytosolic FAT1 protein, whereas keratinocytes, despite comparable FAT1 expression levels, exhibited mainly cell-cell junctional staining PMID: 21680732
    32. FAT1 may be involved in the migration and invasion mechanisms of oral squamous cell carcinoma cells PMID: 21617878
    33. Processing of FAT1 and the translocation of its cytoplasmic domain to the nucleus were studied. PMID: 15922730
    34. A cadherin gene, FAT, confers susceptibility to bipolar disorder in four independent cohorts. In mice, Fat was shown to be significantly downregulated and Catnb and Enah were significantly upregulated in response to therapeutic doses of lithium. PMID: 16402135
    35. Fat1 exhibit co-localisation with Homer-3 in cellular protrusions and at the plasma membrane of HeLa cells PMID: 16979624
    36. results identify mutations in FAT as an important factor in the development of oral cancer and indicate the importance of FATs function in some squamous cell carcinomas PMID: 17325662
    37. FAT1(WT) is up-regulated in migration, induces cellular process formation when overexpressed, and is necessary for efficient wound healing PMID: 17500054
    38. This study did not support the two FAT polymorphism in the affectve disorder. PMID: 17895925
    39. The results of this study supports an involvement of variation at the FAT gene in the etiology of BPAD. PMID: 17938632
    40. Results point to a role of the FAT in astrocytic tumorigenesis and demonstrate the use of RAPD analysis in identifying specific alterations in astrocytic tumors. PMID: 19126244

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  • 亚细胞定位：
    [Protocadherin Fat 1]: Cell membrane; Single-pass type I membrane protein.; [Protocadherin Fat 1, nuclear form]: Nucleus.
  • 组织特异性：
    Expressed in many epithelial and some endothelial and smooth muscle cells.
  • 数据库链接：

    HGNC: 3595

    OMIM: 600976

    KEGG: hsa:2195

    STRING: 9606.ENSP00000406229

    UniGene: Hs.481371

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