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  4. Recombinant Human Protein lyl-1 (LYL1)

Recombinant Human Protein lyl-1 (LYL1)

  • 中文名称：
    人LYL1重组蛋白
  • 货号：
    CSB-YP013258HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人LYL1重组蛋白
  • 货号：
    CSB-EP013258HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人LYL1重组蛋白
  • 货号：
    CSB-EP013258HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人LYL1重组蛋白
  • 货号：
    CSB-BP013258HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人LYL1重组蛋白
  • 货号：
    CSB-MP013258HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    LYL1
  • Uniprot No.：
    P12980
  • 别名：
    bHLHa18; Class A basic helix-loop-helix protein 18; Lyl1; LYL1_HUMAN; Lymphoblastic leukemia derived sequence 1; Lymphoblastic leukemia-derived sequence 1; lymphoblastomic leukemia 1; Protein lyl 1; Protein lyl-1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-280
  • 氨基酸序列
    MCPPQAQAEV GPTMTEKAEM VCAPSPAPAP PPKPASPGPP QVEEVGHRGG SSPPRLPPGV PVISLGHSRP PGVAMPTTEL GTLRPPLLQL STLGTAPPTL ALHYHPHPFL NSVYIGPAGP FSIFPSSRLK RRPSHCELDL AEGHQPQKVA RRVFTNSRER WRQQNVNGAF AELRKLLPTH PPDRKLSKNE VLRLAMKYIG FLVRLLRDQA AALAAGPTPP GPRKRPVHRV PDDGARRGSG RRAEAAARSQ PAPPADPDGS PGGAARPIKM EQTALSPEVR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

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LYL1 antibodies

靶点详情

  • 基因功能参考文献：
    1. Despite not being identified as an independent prognostic factor in UCEC, LYL1 gene amplification is associated with other poor prognostic factors and correlated with upregulation of cancer-related pathways. PMID: 29716549
    2. In t(8;21) leukemia cells, LYL1 functions as a component of the stable AML1-ETO-containing transcription factor complex (AETFC). The AETFC components cooperatively regulate gene expression and contribute to leukemogenesis. PMID: 23812588
    3. LYL1 degradation is directed by a N-terminal PEST rich site in a phosphorylation-independent manner. PMID: 20844761
    4. LYL1 activity is required for the maturation of newly formed blood vessels in adulthood. PMID: 20418284
    5. Over-expression of LYL1 is highly associated with AML as well as ALL. PMID: 19176012
    6. Multiple mechanisms which activate LYL1 in leukemic cells, including structural genomic alterations, namely microdeletion or amplification, together with the involvement of prominent oncogenic transcription factors. PMID: 19608273
    7. LYL1 may play a role in early hematopoiesis and may be a potential oncogenic factor in AML PMID: 16094422
    8. Lyl1 interacts with CREB1 and alters expression of CREB1 target genes. PMID: 18160048

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  • 相关疾病：
    A chromosomal aberration involving LYL1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(7;19)(q35;p13) with TCRB.
  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 6734

    OMIM: 151440

    KEGG: hsa:4066

    STRING: 9606.ENSP00000264824

    UniGene: Hs.46446

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