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  4. Recombinant Human Protein bicaudal D homolog 1 (BICD1), partial

Recombinant Human Protein bicaudal D homolog 1 (BICD1), partial

  • 中文名称：
    Recombinant Human Protein bicaudal D homolog 1(BICD1) ,partial
  • 货号：
    CSB-YP842674HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Protein bicaudal D homolog 1(BICD1) ,partial
  • 货号：
    CSB-EP842674HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Protein bicaudal D homolog 1(BICD1) ,partial
  • 货号：
    CSB-EP842674HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Protein bicaudal D homolog 1(BICD1) ,partial
  • 货号：
    CSB-BP842674HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Protein bicaudal D homolog 1(BICD1) ,partial
  • 货号：
    CSB-MP842674HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    BICD1
  • Uniprot No.：
    Q96G01
  • 别名：
    Bic-D 1; Bicaudal D homolog 1; BICD; Bicd1; BICD1_HUMAN; Cytoskeleton like bicaudal D protein homolog 1; Protein bicaudal D homolog 1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex.
  • 基因功能参考文献：
    1. Data suggest that BICD1 and BICD2 are highly expressed in the nervous system during development and are important in neuronal homeostasis. [REVIEW] PMID: 28215293
    2. This study showed that rs2735940 hTERT CX-TT donor-recipient genotype pair was associated with almost five times higher odds (OR=4.82; 95% CI: 1.32-18; p=0.016) of delayed graft function (DGF), and that rs2735940 hTERT, rs2630578 BICD1, and rs7235755 chromosome 18 polymorphisms combined pairs were not associated with acute rejection (AR). PMID: 28410362
    3. Kidney transplant recipients' polymorphisms of genes associated with telomere length, BICD1 and chromosome 18, but not hTERT, affect kidney allograft early and long-term function after transplantation. PMID: 27496426
    4. Graft BICD1 polymorphisms apart from the association with telomere length, affect early kidney function after transplantation PMID: 25792135
    5. Variants in BICD1 are associated with length of telomeres, which suggests that a mechanism linked to accelerated aging may be involved in the pathogenesis of emphysema. PMID: 20709820
    6. the protease-activated receptor-1 interactor, Bicaudal D1, regulates G protein signaling and internalization PMID: 20164183
    7. Various processes in which BicD is involved during Drosophilian development (review) PMID: 16320833
    8. findings show BICD1 localized to Chlamydia trachomatis inclusions in a biovar-specific manner and that EGFP-BICD1 is recruited to the inclusion in a microtubule- and Golgi apparatus-independent but chlamydial gene expression-dependent mechanism PMID: 17101644
    9. These results imply that GSK-3beta may function in transporting centrosomal proteins to the centrosome by stabilizing the BICD1 and dynein complex, resulting in the regulation of a focused microtubule organization. PMID: 17139249
    10. The brain-specific Rab6B via Bicaudal-D1 is linked to the dynein/dynactin complex, suggesting a regulatory role for Rab6B in the retrograde transport of cargo in neuronal cells. PMID: 17707369
    11. BICD1 plays a similar role in telomere length homeostasis in humans. PMID: 18487243

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  • 亚细胞定位：
    Golgi apparatus.
  • 蛋白家族：
    BicD family
  • 组织特异性：
    Expressed in the brain, heart and skeletal muscle.
  • 数据库链接：

    HGNC: 1049

    OMIM: 602204

    KEGG: hsa:636

    STRING: 9606.ENSP00000281474

    UniGene: Hs.505202

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