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  4. Recombinant Human Protein SON (SON), partial

Recombinant Human Protein SON (SON), partial

  • 中文名称：
    人SON重组蛋白
  • 货号：
    CSB-YP022403HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SON重组蛋白
  • 货号：
    CSB-EP022403HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SON重组蛋白
  • 货号：
    CSB-EP022403HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SON重组蛋白
  • 货号：
    CSB-BP022403HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SON重组蛋白
  • 货号：
    CSB-MP022403HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SON
  • Uniprot No.：
    P18583
  • 别名：
    BASS1; Bax antagonist selected in saccharomyces 1; DBP-5; Negative regulatory element-binding protein; NRE-binding protein; Protein DBP-5; Protein SON; SON; SON protein; SON_HUMAN; SON3
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1.
  • 基因功能参考文献：
    1. We found that SON and SC35 (also known as SRSF2) localize to the central region of the speckle, whereas MALAT1 and small nuclear (sn)RNAs are enriched at the speckle periphery. PMID: 29133588
    2. we have established that haploinsufficiency of SON causes a new recognizable syndrome of intellectual disability. SON is located within 21q22.11, a critical region for Braddock-Carey syndrome, therefore, we suggest that the intellectual disability observed in Braddock-Carey syndrome could be accounted for by haploinsufficiency of SON. PMID: 27256762
    3. description of seven unrelated individuals with de novo variants in SON and propose that deleterious variants in SON are associated with a severe multisystem disorder characterized by developmental delay, persistent feeding difficulties, and congenital malformations, including brain anomalies PMID: 27545676
    4. data highlight SON as a master regulator governing neurodevelopment and demonstrate the importance of SON-mediated RNA splicing in human development. PMID: 27545680
    5. progenitors. Our findings define SON as a fine-tuner of the MLL-menin interaction and reveal short SON overexpression as a marker indicating aberrant transcriptional initiation in leukemia. PMID: 26990989
    6. Here, we summarize available information from several early studies on SON, and highlight recent discoveries describing molecular mechanisms of SON-mediated gene regulation. PMID: 24030980
    7. identify the spliceosome-associated factor SON as a factor essential for the maintenance of hESCs PMID: 24013217
    8. Studied knockdown screening of 78 MAPK-associated molecules associated with proliferation of pancreatic cancer cells in vitro. Knockdown of SON substantially suppressed pancreatic cancer cell proliferation and survival in vitro and tumorigenicity in vivo. PMID: 23227827
    9. SON protein regulates GATA-2 through transcriptional control of the microRNA 23a~27a~24-2 cluster PMID: 23322776
    10. The data show that Son-regulated splicing encompasses all known types of alternative splicing, the most common being alternative splicing of cassette exons. PMID: 22193954
    11. The identification of the RNA/DNA-binding protein SON as a component of spliceosome that plays pleiotropic roles during mitotic progression, is reported. PMID: 20581448
    12. Results reveal a mechanism for controlling cell-cycle progression through SON-dependent constitutive splicing at suboptimal splice sites, with strong implications for its role in cancer and other human diseases. PMID: 21504830
    13. Data suggest that Son is essential for appropriate subnuclear organization of pre-mRNA splicing factors and for promoting normal cell cycle progression. PMID: 20053686
    14. SON is an indispensable factor for cell growth, and AML1-ETO binding to SON may trigger signals inhibiting leukemogenesis. PMID: 18952841

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  • 相关疾病：
    ZTTK syndrome (ZTTKS)
  • 亚细胞定位：
    Nucleus speckle. Note=Colocalizes with the pre-mRNA splicing factor SRSF2.
  • 组织特异性：
    Widely expressed, with the higher expression seen in leukocyte and heart.
  • 数据库链接：

    HGNC: 11183

    OMIM: 182465

    KEGG: hsa:6651

    STRING: 9606.ENSP00000348984

    UniGene: Hs.517262

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