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  4. Recombinant Human Protein NLRC3 (NLRC3), partial

Recombinant Human Protein NLRC3 (NLRC3), partial

  • 中文名称：
    人NLRC3重组蛋白
  • 货号：
    CSB-YP759614HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人NLRC3重组蛋白
  • 货号：
    CSB-EP759614HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人NLRC3重组蛋白
  • 货号：
    CSB-EP759614HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人NLRC3重组蛋白
  • 货号：
    CSB-BP759614HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人NLRC3重组蛋白
  • 货号：
    CSB-MP759614HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    NLRC3
  • Uniprot No.：
    Q7RTR2
  • 别名：
    CARD15-like ; CARD15-like protein; Caterpiller 16.2; Caterpiller protein 16.2; CLR16.2; FLJ00348; NLR family CARD domain containing 3; Nlrc3; NLRC3_HUMAN; NOD-like receptor C3; NOD3; NOD3 protein; Nucleotide-binding oligomerization domain protein 3; Nucleotide-binding oligomerization domain protein 3 caterpiller 16.2; nucleotide-binding oligomerization domain; leucine rich repeat and CARD domain containing 3; Protein NLRC3
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Negative regulator of the innate immune response. Attenuates signaling pathways activated by Toll-like receptors (TLRs) and the DNA sensor STING/TMEM173 in response to pathogen-associated molecular patterns, such as intracellular poly(dA:dT), but not poly(I:C), or in response to DNA virus infection, including that of Herpes simplex virus 1 (HSV1). May affect TLR4 signaling by acting at the level of TRAF6 ubiquitination, decreasing the activating 'Lys-63'-linked ubiquitination and leaving unchanged the degradative 'Lys-48'-linked ubiquitination. Inhibits the PI3K-AKT-mTOR pathway possibly by directly interacting with the posphatidylinositol 3-kinase regulatory subunit p85 (PIK3R1/PIK3R2) and disrupting the association between PIK3R1/PIK3R2 and the catalytic subunit p110 (PIK3CA/PIK3CB/PIK3CD) and reducing PIK3R1/PIK3R2 activation. Via its regulation of the PI3K-AKT-mTOR pathway, controls cell proliferation, predominantly in intestinal epithelial cells. May also affect NOD1- or NOD2-mediated NF-kappa-B activation. Might also affect the inflammatory response by preventing NLRP3 inflammasome formation, CASP1 cleavage and IL1B maturation.
  • 基因功能参考文献：
    1. NLRC3 promoted K48-linked polyubiquitination and degradation of interleukin-1 receptor-associated kinase 1 (IRAK1). PMID: 28731142
    2. The NLRC3 interferes with the assembly and activity of the NALP3 inflammasome complex by competing with ASC for pro-caspase-1 binding. PMID: 28584053
    3. The extent of NLRC3 and AIM2 gene reduction was correlated with cancer progression. PMID: 26378020
    4. overexpression of NLRC3 with NLRP3/cryopyrin inflammasome components suppresses pro-caspase-1 cleavage and IL-1beta processing. PMID: 25277106
    5. NLRC3 inhibited Toll-like receptor (TLR)-dependent activation of the transcription factor NF-kappaB by interacting with the TLR signaling adaptor TRAF6 PMID: 22863753
    6. This report describes the first cloning and characterization of a novel CATERPILLER gene, CLR16.2 that is located on human chromosome 16. The protein encoded by this gene has a typical NBD-LRR configuration. PMID: 15705585

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    NLRP family
  • 数据库链接：

    HGNC: 29889

    OMIM: 615648

    KEGG: hsa:197358

    UniGene: Hs.592091

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