Recombinant Human Protein KIBRA (WWC1), partial

1. KIBRA rs17070145 is associated with accelerated cognitive decline in APOE epsilon4-positive cognitively normal adults with high Abeta-amyloid burden. PMID: 29391469
2. the overall data in the present meta-analysis revealed a significant association of KIBRA polymorphism rs17070145 and risk of Alzheimer disease. [meta-analysis] PMID: 28859866
3. the study indicated that loss of WWC1 may contribute to podocyte apoptosis by inducing nuclear relocation of dendrin protein, which provided novel insight into the molecular events in podocyte apoptosis. PMID: 28990091
4. that APOE and KIBRA have region-dependent additive and epistatic interactions on brain connectivity in healthy young adults PMID: 27620974
5. In younger adults, no effects of KIBRA were found PMID: 29032191
6. Data show that promoter methylation is a major mechanism involved in KIBRA expression regulation. KIBRA expression levels are reduced in clear cell renal cell carcinoma (ccRCC) and alterations in the balance of KIBRA/SP1 binding by promoter methylation may be involved in the onset and/or progression of ccRCC. PMID: 29046731
7. our results suggest that the effect of the WWC1 rs17070145 polymorphism on memory performance and Alzheimer's disease might be due to a differential regulation of the MAPK signaling, a key pathway involved in memory and learning processes PMID: 28380666
8. we report for the first time that CRB3 acts as an upstream regulator of the Hippo pathway to regulate contact inhibition by recruiting other Hippo molecules, such as Kibra and/or FRMD6, in mammary epithelial cells. PMID: 28079891
9. Ability to navigate in the wilderness benefits from episodic memory (KIBRA). PMID: 27123786
10. Study identifies four likely Tourette disorder risk genes with multiple de novo damaging variants in unrelated probands: WWC1 (WW and C2 domain containing 1), CELSR3 (Cadherin EGF LAG seven-pass G-type receptor 3), NIPBL (Nipped-B-like), and FN1 (fibronectin 1). PMID: 28472652
11. study provides a mechanistic link between aberrant tau acetylation, KIBRA deficiency, and dementia in Alzheimer's disease PMID: 27041503
12. show that KIBRA is overexpressed in human prostate tumors. Our studies uncover unexpected results and identify KIBRA as a tumor promoter in prostate cancer PMID: 27220053
13. No significant differences in allelic or gene frequency distribution of KIBRA SNP rs17070145 were observed between schizophrenic and healthy control groups. PMID: 27060629
14. WWC1 variants are involved in AMPA receptor trafficking and neuronal plasticity, which are associated with cognitive impairment and schizophrenia susceptibility. PMID: 26405221
15. Study observed a trend for a better memory performance and significantly higher volumes and better microstructural integrity in the subfields comprising the CA2/3 and CA4/DG of the hippocampus in KIBRA T-allele carriers compared with non-T-carriers PMID: 26156558
16. decreased expression of the KIBRA gene on both mRNA and protein levels in depression, is reported. PMID: 26768155
17. Phosphorylation-dependent regulation of the DNA damage response of Kibra protein in cancer cells PMID: 26929199
18. Study did not find support for an association of KIBRA either alone or in combination with CLSTN2 with memory performance or hippocampal volume, nor did variation in these genes influence longitudinal memory decline or hippocampal atrophy in older adults PMID: 26415670
19. KIBRA rs17070145 affects specific phenotypes (high alcohol consumption, APOE synergism) of Japanese patients with Alzheimer disease in an age-dependent manner. Right inferior frontal gyrus hyperperfusion was seen in the C allele carrier group. PMID: 25800888
20. the study demonstrates an association between the KIBRA gene and episodic memory (immediate free recall) and suggests a differential effect of this genetic variant in early-onset schizophrenia and healthy siblings PMID: 25146696
21. In brief, we showed that individuals with MD[major depression] that were WWC1 rs17070145TT carriers reported more severe 'concentration difficulties' than C-carriers. PMID: 25656173
22. The results of this study supports the view that effects of KIBRA and CLSTN2 polymorphisms genetic polymorphisms on cognitive functioning may be most easily disclosed at suboptimal levels of cognitive ability, such as in old-age depression. PMID: 25080189
23. KIBRA is involved in human tumorigenesis and other physiological processes including cell polarity, membrane/vesicular trafficking, mitosis and cell migration. PMID: 24642126
24. KIBRA/WWC1 rs17070145 polymorphism has effect on spatial memory in humans and age differences in the reliance on landmark and boundary-related spatial information. PMID: 23733450
25. overexpression of Kibra rescues the increased cell migration and aberrant three-dimensional morphogenesis induced by knockdown of PTPN14, and this rescue is mediated through the activation of the upstream LATS1 kinase PMID: 25023289
26. Results show a dynamic relationship between WWC1 rs17070145 polymorphism and increasing age on neuronal activity in the hippocampal region and cognitive performance PMID: 24290728
27. study reveals an association between two WWC1 SNPs and the likelihood of PTSD development. PMID: 23582269
28. Data indicate transcription factor TCF7L2 as a regulator of KIBRA gene expression. PMID: 24072042
29. KIBRA knockdown impaired cell migration and proliferation in breast cancer cells. PMID: 24269383
30. KIBRA might associate with younger Alzheimer's disease patients (PMID: 24190487
31. exonic missense variants in the C2 domain modify lipid binding and cognitive performance PMID: 23778582
32. This study demonistrated that KIBRA T-allele (rs17070145) had a larger hippocampal volume relative to noncarriers. The structural differences observed were specific to the CA fields and DG regions of the hippocampus. PMID: 23926262
33. findings suggest that the polymorphism in the KIBRA gene affects matter volume and the function of the default-mode network and executive control network PMID: 23266749
34. High expression of KIBRA is correlated with lymphatic (P = 0.046) and venous invasion (P = 0.039). PMID: 23163744
35. Decreased expression of KIBRA is associated with breast cancer. PMID: 22614006
36. The results suggest that the KIBRA rs17070145 T-allele effects are specific to episodic memory and support the hypothesis that associations between rs17070145 variation and memory are disparate between healthy and impaired populations. PMID: 22794909
37. findings indicate that SNP rs17070145 located within KIBRA explains 0.5 percent of the variance for episodic memory tasks and 0.1 percent of the variance for working memory tasks in samples of primarily Caucasian background PMID: 23065961
38. the KIBRA-Aurora-Lats2 protein complexes form a novel axis that regulates precise mitosis. PMID: 22904328
39. identified KIBRA Ser(542) and Ser(931) as main phosphorylation sites for CDK1 both in vitro and in vivo PMID: 22784093
40. KIBRA genotype, as well as the number of intake drug abuse problems and a younger age, were associated with an increased risk of relapse PMID: 22129841
41. analysis of clinical-pathological parameters showed that KIBRA methylation was associated with unfavorable biological prognostic parameters, including unmutated IGHV genes (p = 0.007) and high CD38 expression (p < 0.05). PMID: 22430796
42. No increased risk of any type of late development, and cognitive impairment was associated with KIBRA (rs17070145) PMID: 21643791
43. Potential associations of the common KIBRA rs17070450 genotype are comprehensively tested with cognitive functions in a medically well-characterized cohort of community-dwelling elderly individuals. PMID: 21346737
44. KIBRA protein phosphorylation is regulated by mitotic kinase aurora and protein phosphatase 1. PMID: 21878642
45. Enhanced memory performance in KIBRA T allele carriers is linked to elevated hippocampal functioning, rather than to neural compensation in noncarriers. PMID: 21976506
46. These results indicate that KIBRA regulates higher brain function by regulating AMPAR trafficking and synaptic plasticity. PMID: 21943600
47. The results strongly support the notion that KIBRA regulates epithelial cell polarity by suppressing apical exocytosis through direct inhibition of aPKC kinase activity in the PAR3-aPKC-PAR6 complex. PMID: 21497093
48. KIBRA methylation occurs frequently in B-cell acute lymphocytic leukemia but not in epithelial cancers and is linked to specific genetic event in B-ALL. PMID: 21173572
49. The results of this study suggested a modest role for KIBRA as a cognition and AD risk gene, and also highlight the multifactorial complexity of its genetic associations. PMID: 21185624
50. a pooled GWAS study undertaken to find novel genes associated with episodic memory performance; a genomic locus for KIBRA was found to be associated with memory performance in three cognitively normal cohorts from Switzerland and the USA PMID: 21204039

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HGNC: 29435

OMIM: 610533

KEGG: hsa:23286

STRING: 9606.ENSP00000427772

UniGene: Hs.484047