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  4. Recombinant Human Protein Jumonji (JARID2), partial

Recombinant Human Protein Jumonji (JARID2), partial

  • 中文名称：
    人JARID2重组蛋白
  • 货号：
    CSB-YP852915HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人JARID2重组蛋白
  • 货号：
    CSB-EP852915HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人JARID2重组蛋白
  • 货号：
    CSB-EP852915HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人JARID2重组蛋白
  • 货号：
    CSB-BP852915HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人JARID2重组蛋白
  • 货号：
    CSB-MP852915HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    JARID2
  • Uniprot No.：
    Q92833
  • 别名：
    JARD2; JARD2_HUMAN; JARID2; JMJ; Jumonji AT rich interactive domain 2 ; Jumonji homolog; Jumonji like protein; Jumonji protein; Jumonji/ARID domain containing protein 2; Jumonji/ARID domain-containing protein 2; Protein Jumonji
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

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JARID2 antibodies

靶点详情

  • 功能：
    Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts as an accessory subunit for the core PRC2 (Polycomb repressive complex 2) complex, which mediates histone H3K27 (H3K27me3) trimethylation on chromatin. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells, thereby playing a key role in stem cell differentiation and normal embryonic development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling. Does not have histone demethylase activity.
  • 基因功能参考文献：
    1. rs2237126 in JARID2 is not significantly associated with childhood autism spectrum disorder or the severity of the disease in a Chinese Han population. PMID: 29216786
    2. The knockdown of JARID2 inhibited the viability and invasion of trophoblast cells in preeclampsia by suppressing the PI3K/Akt signaling pathway. PMID: 28714012
    3. bservations suggested that knockdown of JARID2 inhibited proliferation, migration and invasion in vitro through the inactivation of the PI3K/Akt signaling pathway. Therefore, JARID2 may represent a potential therapeutic target for the treatment of ovarian cancer. PMID: 28765957
    4. Authors found that knockdown of Jarid2 was able to inhibit the invasive ability and sphere-forming capacity in bladder cancer cells. PMID: 28445934
    5. Our results suggest that JARID2 rs2237138 shows a protective effect against NSCL +/- P (non-syndromic oral clefts)in the Brazilian population. PMID: 27328068
    6. JARID2 promotes invasion and metastasis of hepatocellular carcinoma by facilitating epithelial-mesenchymal transition through PTEN/AKT signaling PMID: 27259236
    7. JARID2 plays an important role in glioma development. PMID: 27641964
    8. Data further strengthen the conclusion that JARID2 polymorphisms are associated with NSOC susceptibility. PMID: 25155265
    9. JARID2 inhibits leukemia cell proliferation by regulating CCND1 expression PMID: 25939703
    10. TGF-ss-dependent expression changes of EMT-related genes were inhibited by JARID2 knockdown and enhanced by JARID2 overexpression. PMID: 25542019
    11. Results suggest a regulation loop where Jarid2 protein methylation fine-tunes polycomb repressive complex 2 (PRC2) activity depending on the chromatin context. PMID: 25620564
    12. Jarid2 is an important component of PRC2 that has a central role in coordinating hematopoietic stem and progenitor cell function PMID: 25645357
    13. Decreased miRNA-940 affects the proliferation and migration of the progenitor cells of the secondary heart field by targeting JARID2. PMID: 24889693
    14. miR-155 regulates the fate of Th17 and Treg cells and miR-155 contributes to Th17 cell function by suppressing the inhibitory effects of Jarid2. PMID: 24856900
    15. The interaction of JARID2 at these promoters is dependent on EED. PMID: 23435416
    16. Jarid2 is an important mediator of Xist-induced PRC2 targeting. PMID: 24462204
    17. The presence of long noncoding RNAs stimulated JARID2-EZH2 interactions in vitro and JARID2-mediated recruitment of PRC2 to chromatin. PMID: 24374312
    18. Patients carrying JARID2 deletion manifested with cognitive impairment, gait disturbance and a characteristic facial appearance, whereas patients with deletion of ATXN1 seemed to be characterized by intellectual disability and behavioural abnormalities PMID: 23294540
    19. In chronic myeloproliferative neoplasms & myelodysplastic syndromes, there were frequent deletions in a 1.1 Mb region of the short arm of chromosome 6 containing only the JARID2 gene. This del6p was associated with leukemic transformation. PMID: 22190018
    20. JARID2 is essential for the binding of PcG proteins to target genes and, consistent with this, for the proper differentiation of embryonic stem cells and normal development PMID: 20075857
    21. Two SNPs in JARID2 showed association in allelic, genotypic and haplotypic tests with schizophrenia patients from Chang Le area. PMID: 19884986
    22. JMJ was evaluated against risk factors for spinal dysraphism and congenital heart defects. Variations within exons and introns of JMJ might be in linkage disequlibrium. PMID: 15057990
    23. JARID2 should be viewed as a candidate gene for 6p22.3-linked schizophrenia PMID: 16967465
    24. JARID2 appears important in transcriptional regulation of fetal genes and may emerge as a diagnostic marker for left ventricular decompensation in aortic stenosis. PMID: 18805276
    25. Based on the findings the authors propose that miR-155 has a prosurvival function that is mediated through the downregulation of targets including JARID2. PMID: 19759154

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    During embryogenesis, predominantly expressed in neurons and particularly in dorsal root ganglion cells.
  • 数据库链接：

    HGNC: 6196

    OMIM: 601594

    KEGG: hsa:3720

    STRING: 9606.ENSP00000341280

    UniGene: Hs.269059

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