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  4. Recombinant Human Proteasome-associated protein ECM29 homolog (ECM29), partial

Recombinant Human Proteasome-associated protein ECM29 homolog (ECM29), partial

  • 中文名称：
    人ECM29重组蛋白
  • 货号：
    CSB-YP736206HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人ECM29重组蛋白
  • 货号：
    CSB-EP736206HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人ECM29重组蛋白
  • 货号：
    CSB-EP736206HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人ECM29重组蛋白
  • 货号：
    CSB-BP736206HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人ECM29重组蛋白
  • 货号：
    CSB-MP736206HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ECM29
  • Uniprot No.：
    Q5VYK3
  • 别名：
    ECPAS; ECM29; KIAA0368Proteasome adapter and scaffold protein ECM29; Ecm29 proteasome adapter and scaffold; Proteasome-associated protein ECM29 homolog
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolysis. Promotes proteasome dissociation under oxidative stress.
  • 基因功能参考文献：
    1. Data suggest that the adapter protein ECM29 is the main proteasome-interacting protein responsible for oxidative stress-induced proteasome disassembly/remodeling; ECM29 appears to intrude on interaction between the 20S core particle and 19S regulatory particle in 26S proteasome, disrupting proteasome structure in response to oxidative stress. PMID: 28821611
    2. Ecm29 is involved in the dissociation process of 26S proteasome, providing clue to analyse the mechanism of proteasomal degradation under various stress condition. PMID: 26802743
    3. The absence of Ecm29 enhanced TLR3 signaling, which was characterized by the increased abundance of the adaptor protein and E3 ubiquitin ligase tumor necrosis factor receptor-associated factor 3 PMID: 24084648
    4. Ecm29 serves as an adaptor for coupling 26 S proteasomes to specific cellular compartments. PMID: 20682791
    5. Ecm29 protein serves to couple the 26 S proteasome to secretory compartments engaged in quality control and to other sites of enhanced proteolysis PMID: 15496406

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  • 亚细胞定位：
    Endoplasmic reticulum. Endoplasmic reticulum-Golgi intermediate compartment. Endosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Endosome, multivesicular body. Cytoplasmic vesicle.
  • 蛋白家族：
    ECM29 family
  • 数据库链接：

    HGNC: 29020

    OMIM: 616694

    STRING: 9606.ENSP00000259335

    UniGene: Hs.368255

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