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  4. Recombinant Human Probable ubiquitin carboxyl-terminal hydrolase FAF-Y (USP9Y), partial

Recombinant Human Probable ubiquitin carboxyl-terminal hydrolase FAF-Y (USP9Y), partial

  • 中文名称：
    人USP9Y重组蛋白
  • 货号：
    CSB-YP025755HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人USP9Y重组蛋白
  • 货号：
    CSB-EP025755HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人USP9Y重组蛋白
  • 货号：
    CSB-EP025755HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人USP9Y重组蛋白
  • 货号：
    CSB-BP025755HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人USP9Y重组蛋白
  • 货号：
    CSB-MP025755HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    USP9Y
  • Uniprot No.：
    O00507
  • 别名：
    AZF 1; AZF; AZF1; AZFA; Azoospermia factor 1; Deubiquitinating enzyme FAF Y; Deubiquitinating enzyme FAF-Y; DFFRY; Fat facets like; Fat facets like Drosophila; Fat facets protein related Y linked; Fat facets protein-related; Probable ubiquitin carboxyl terminal hydrolase FAF Y; Probable ubiquitin carboxyl-terminal hydrolase FAF-Y; SP 3; SP3; SPGFY2; Ubiquitin specific peptidase 9 Y linked; Ubiquitin specific processing protease FAF Y; Ubiquitin specific protease 9 Y chromosome; Ubiquitin thioesterase FAF Y; Ubiquitin thiolesterase FAF-Y; Ubiquitin-specific protease 9; Ubiquitin-specific-processing protease FAF-Y; USP 10; USP 9Y; USP10; USP9Y; USP9Y_HUMAN; Y chromosome; Y-linked
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade. Deubiquitination of SMAD4 by USP9X re-empowers its competence to mediate TGF-beta signaling.
  • 基因功能参考文献：
    1. This is the first research investigating the utility of TTTY15-USP9Y in prostate cancer detection PMID: 26008593
    2. An impact of the identified polymorphism on discrimination of alleles of the M46 locus with various techniques was discussed, and solutions ensuring correctness of the genotyping results were proposed. PMID: 23650841
    3. detection of mrna in azooermic men PMID: 11869379
    4. results suggest that, through de-ubiquitination, ubiquitin specific protease 9(USP9Y) may stabilize a specific target protein that is important for male germ cell development PMID: 12895410
    5. Selection is acting to maintain the amino acid sequence of both the X and the Y-linked genes. PMID: 12925892
    6. Findings indicated that AZF microdeletion and chromosomal abnormality should be important causes of male infertility. PMID: 15696490
    7. rare Y chromosome missense mutation in exon 25 of human USP9Y revealed by pyrosequencing PMID: 18205040
    8. Frequency of AZF microdeletions in peripheral leukocytes and testicular cells in Chinese men with idiopathic infertility. PMID: 18357961

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  • 相关疾病：
    Spermatogenic failure Y-linked 2 (SPGFY2)
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Peptidase C19 family
  • 组织特异性：
    Widely expressed in embryonic and adult tissues.
  • 数据库链接：

    HGNC: 12633

    OMIM: 400005

    KEGG: hsa:8287

    STRING: 9606.ENSP00000342812

    UniGene: Hs.598540

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