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  4. Recombinant Human Probable phospholipid-transporting ATPase IH (ATP11A), partial

Recombinant Human Probable phospholipid-transporting ATPase IH (ATP11A), partial

  • 中文名称：
    Recombinant Human Probable phospholipid-transporting ATPase IH(ATP11A) ,partial
  • 货号：
    CSB-YP002313HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Probable phospholipid-transporting ATPase IH(ATP11A) ,partial
  • 货号：
    CSB-EP002313HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Probable phospholipid-transporting ATPase IH(ATP11A) ,partial
  • 货号：
    CSB-EP002313HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Probable phospholipid-transporting ATPase IH(ATP11A) ,partial
  • 货号：
    CSB-BP002313HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Probable phospholipid-transporting ATPase IH(ATP11A) ,partial
  • 货号：
    CSB-MP002313HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ATP11A
  • Uniprot No.：
    P98196
  • 别名：
    AT11A; AT11A_HUMAN; Atp11a; ATPase class VI type 11A; ATPase IS; ATPIH; ATPIS; P4-ATPase flippase complex alpha subunit ATP11A; Probable phospholipid-transporting ATPase IH
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane. Contributes to the maintenance of membrane lipid asymmetry with a specific role in morphogenesis of muscle cells. In myoblasts, mediates PS enrichment at the inner leaflet of plasma membrane, triggering PIEZO1-dependent Ca2+ influx and Rho GTPases signal transduction, subsequently leading to the assembly of cortical actomyosin fibers and myotube formation. May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib.
  • 基因功能参考文献：
    1. The lipid flippases, ATP8B1 and ATP11A are novel elements of the innate immune response that are essential to attenuate the inflammatory response, possibly by mediating endotoxin-induced internalization of TLR4. PMID: 27628304
    2. ATP11A is a useful predictive marker of metastasis in colorectal cancer patients. PMID: 20043114
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Early endosome. Recycling endosome. Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Cation transport ATPase (P-type) (TC 3.A.3) family, Type IV subfamily
  • 组织特异性：
    Widely expressed. Expressed in myoblasts.
  • 数据库链接：

    HGNC: 13552

    OMIM: 605868

    KEGG: hsa:23250

    STRING: 9606.ENSP00000283558

    UniGene: Hs.29189

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