Recombinant Human Probable E3 ubiquitin-protein ligase RNF144A (RNF144A), partial

中文名称：

人RNF144A重组蛋白
货号：

CSB-YP019840HU1
规格：
来源：

Yeast
其他：

中文名称：

人RNF144A重组蛋白
货号：

CSB-EP019840HU1
规格：
来源：

E.coli
其他：

中文名称：

人RNF144A重组蛋白
货号：

CSB-EP019840HU1-B
规格：
来源：

E.coli
共轭：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名称：

人RNF144A重组蛋白
货号：

CSB-BP019840HU1
规格：
来源：

Baculovirus
其他：

中文名称：

人RNF144A重组蛋白
货号：

CSB-MP019840HU1
规格：
来源：

Mammalian cell
其他：

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纯度：

>85% (SDS-PAGE)
基因名：

RNF144A
Uniprot No.：

P50876
别名：

RNF144A; KIAA0161; RNF144; UBCE7IP4; E3 ubiquitin-protein ligase RNF144A; RING finger protein 144A; UbcM4-interacting protein 4; Ubiquitin-conjugating enzyme 7-interacting protein 4
种属：

Homo sapiens (Human)
蛋白长度：

Partial
蛋白标签：

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
产品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
复溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
储存条件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保质期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
货期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事项：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

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功能：

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC.
基因功能参考文献：
1. both proper membrane localization and self-association are important for RNF144A function. PMID: 26216882
2. The regulation of DNA-PKcs by RNF144A is important for proper apoptotic response during DNA damage, suggesting a tumor suppressor function for RNF144A. PMID: 24979766
3. Clinical trial and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20195266
4. Functional analysis of the mouse counterpart. PMID: 10431818
亚细胞定位：

Cell membrane; Single-pass membrane protein. Cytoplasmic vesicle membrane.
蛋白家族：

RBR family, RNF144 subfamily
数据库链接：

HGNC: 20457

KEGG: hsa:9781

STRING: 9606.ENSP00000321330

UniGene: Hs.22146

Recombinant Human Probable E3 ubiquitin-protein ligase RNF144A (RNF144A), partial

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