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  4. Recombinant Human Prion-like protein doppel (PRND)

Recombinant Human Prion-like protein doppel (PRND)

  • 中文名称：
  • 货号：
    CSB-YP890741HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
  • 货号：
    CSB-EP890741HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
  • 货号：
    CSB-EP890741HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
  • 货号：
    CSB-BP890741HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
  • 货号：
    CSB-MP890741HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PRND
  • Uniprot No.：
    Q9UKY0
  • 别名：
    Prion-like protein doppel; PrPLP; Prion protein 2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    26-152aa
  • 氨基酸序列
    TRGIKHRIKWNRKALPSTAQITEAQVAENRPGAFIKQGRKLDIDFGAEGNRYYEANYWQFPDGIHYNGCSEANVTKEAFVTGCINATQAANQGEFQKPDNKLHQQVLWRLVQELCSLKHCEFWLERG
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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PRND antibodies

靶点详情

  • 功能：
    Required for normal acrosome reaction and for normal male fertility. Can bind Cu(2+).
  • 基因功能参考文献：
    1. results demonstrate that blocking doppel can control VEGF signaling in TECs and selectively inhibit tumor angiogenesis. PMID: 26950422
    2. The association between the APOE, CYP46, PRNP and PRND genes and the profile of neuropsychiatric symptoms in Polish subjects with Alzheimer's disease and mild cognitive impairment, was evaluated. PMID: 22453181
    3. in astrocytomas, Dpl undergoes different molecular processes that might constitute additional helpful tools to characterize the glial tumor progression PMID: 20981146
    4. Cytotoxicity induced by the expression of Dpl and truncated PrP in neural derived cells are closely related with the apoptosis process. PMID: 19728151
    5. expression pattern and biochemical characteristics in human tissues and in Chinese hamster ovary cells transfected with wild-type or variant human Dpl gene constructs PMID: 12200435
    6. Doppel expression is not modified in the brains of patients with Creutzfeldt-Jakob disease. PMID: 12586339
    7. human Doppel fails to interact with itself; Dpl and PrP are not related or are only marginally related with respect to their ligand binding behaviour PMID: 15158907
    8. results demonstrate that Doppel and PrPc co-patch extensively at the plasma membrane PMID: 15203115
    9. Doppel interacts with the full-length laminin receptor precursor protein PMID: 15246873
    10. Doppel is expressed early during ontogenesis, and is found in both germ cells and Sertoli cells. Doppel may play a physiological role in acrosome biogenesis. PMID: 16421231
    11. Extensive differences in PRND gene expression were also found within each grade of malignancy, suggesting that PRND mRNA quantitation might be useful to distinguish astrocytoma subtypes. PMID: 17390034
    12. Study provides the foundation for further study of Dpl biological functions in vitro and in vivo. PMID: 17894227
    13. Results might suggest a potential and functional role for Dpl in tumor cells migratory and morphological behaviours and address to future gene-targeted therapeutic interventions. PMID: 18936526
    14. results suggested that the function of Dpl is antagonistic to PrP rather than synergistic PMID: 19129949

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族：
    Prion family
  • 组织特异性：
    Expressed in testis, in Sertoli cells, ejaculated spermatozoa and in seminal fluid (at protein level).
  • 数据库链接：

    HGNC: 15748

    OMIM: 604263

    KEGG: hsa:23627

    STRING: 9606.ENSP00000306900

    UniGene: Hs.406696

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