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  4. Recombinant Human Prickle-like protein 1 (PRICKLE1), partial

Recombinant Human Prickle-like protein 1 (PRICKLE1), partial

  • 中文名称：
    人PRICKLE1重组蛋白
  • 货号：
    CSB-YP850396HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PRICKLE1重组蛋白
  • 货号：
    CSB-EP850396HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PRICKLE1重组蛋白
  • 货号：
    CSB-EP850396HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PRICKLE1重组蛋白
  • 货号：
    CSB-BP850396HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PRICKLE1重组蛋白
  • 货号：
    CSB-MP850396HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PRICKLE1
  • Uniprot No.：
    Q96MT3
  • 别名：
    PRICKLE1; RILPPrickle-like protein 1; REST/NRSF-interacting LIM domain protein 1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor.
  • 基因功能参考文献：
    1. upregulation of PRICKLE1 in basal breast cancers, a subtype characterized by high metastatic potential, is associated with poor metastasis-free survival. PMID: 27184734
    2. these findings suggest PRICKLE1 mutations contribute to ASD by disrupting the interaction with SYN1 and regulation of synaptic vesicles. PMID: 24312498
    3. study demonstrates that PRICKLE1 could act as a predisposing factor to human neural tube defects PMID: 21901791
    4. MINK1 interacts with and phosphorylates PRICKLE1 and PRICKLE2. PMID: 22037766
    5. Mutations in prickle1 causes seizures. PMID: 21276947
    6. PRICKLE1 mutations are not a frequent cause of progressive myoclous epilepsies in Southern Italy. PMID: 20842693
    7. PRICKLE1 and PRICKLE2 mRNAs were expressed together in brain, eye and testis. PMID: 12525887
    8. appears to serve as a nuclear receptor for REST/NRSF, REST4, and possibly other transcription factors PMID: 14645515
    9. NRSF/REST functions as a repressor of TH transcription in NSCs via a mechanism dependent on the TH NRSE/RE1 sites. PMID: 16764822
    10. Prickle-1 is a negative regulator of the Wnt/beta-catenin signaling pathway and is a putative tumor suppressor in human hepatocellular carcinoma PMID: 17030191
    11. there is synergism between REST and NFkappaB in the suppression of TAC1 in non-neuronal cells PMID: 17709376
    12. A homozygous mutation in PRICKLE1 causes an autosomal-recessive progressive myoclonus epilepsy-ataxia syndrome. PMID: 18976727
    13. A physical and functional interaction between Prickle and Strabismus was found in Drosophila and Xenopus, but is likely conserved in human, too. PMID: 12941693

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  • 相关疾病：
    Epilepsy, progressive myoclonic 1B (EPM1B); Neural tube defects (NTD)
  • 亚细胞定位：
    Nucleus membrane. Cytoplasm, cytosol. Note=A smaller amount is detected in the cytosol.
  • 蛋白家族：
    Prickle / espinas / testin family
  • 组织特异性：
    Expressed at highest levels in placenta and at lower levels in lung, liver, kidney and pancreas. Expressed in thalamus, hippocampus, cerebral cortex, and cerebellum (in neurons rather than glia).
  • 数据库链接：

    HGNC: 17019

    OMIM: 182940

    KEGG: hsa:144165

    STRING: 9606.ENSP00000345064

    UniGene: Hs.524348

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