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  4. Recombinant Human Potassium-transporting ATPase alpha chain 1 (ATP4A), partial

Recombinant Human Potassium-transporting ATPase alpha chain 1 (ATP4A), partial

  • 中文名称：
    Recombinant Human Potassium-transporting ATPase alpha chain 1(ATP4A) ,partial
  • 货号：
    CSB-YP002342HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Potassium-transporting ATPase alpha chain 1(ATP4A) ,partial
  • 货号：
    CSB-EP002342HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Potassium-transporting ATPase alpha chain 1(ATP4A) ,partial
  • 货号：
    CSB-BP002342HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Potassium-transporting ATPase alpha chain 1(ATP4A) ,partial
  • 货号：
    CSB-MP002342HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ATP4A
  • Uniprot No.：
    P20648
  • 别名：
    Atp4a; ATP4A_HUMAN; ATP6A; ATPase H+/K+ exchanging alpha polypeptide; ATPase H+/K+ transporting alpha polypeptide; Gastric H K ATPase alpha subunit; Gastric H K ATPase catalytic subunit; Gastric H(+)/K(+) ATPase subunit alpha; Gastric H+/K+ ATPase alpha subunit; Gastric hydrogen potassium ATPase; H(+) K(+) ATPase alpha subunit ; Potassium-transporting ATPase alpha chain 1; Proton pump
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

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ATP4A Proteins

靶点详情

  • 功能：
    The catalytic subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Uses ATP as an energy source to pump H(+) ions to the gastric lumen while transporting K(+) ion from the lumen into the cell. Remarkably generates a million-fold proton gradient across the gastric parietal cell membrane, acidifying the gastric juice down to pH 1. Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). The release of the H(+) ion in the stomach lumen is followed by binding of K(+) ion converting the pump conformation back to the E1 state.
  • 基因功能参考文献：
    1. ATP4A antibodies were present in a significant proportion of children with type 1 diabetes (T1D). Higher ATP4A levels in T1D children are associated with lower, yet still fitting within the normal range, levels of vitamin B12, and ferritin. PMID: 28401620
    2. Heterozygous mutations in the ATP4A and PTH1R genes were identified in a family with type I gastric neuroendocrine tumors plus hypothyroidism and rheumatoid arthritis PMID: 28474257
    3. the generation and characterization of a knockin mouse model for the ATP4a(R703C) mutation to better understand the tumorigenesis process. PMID: 27491072
    4. In conclusion, patients homozygous for an inactivating ATP4A mutation develop gastric ECL-cell carcinoids in their 3rd or 4th decade. PMID: 27150581
    5. Homozygous missense mutation in the 14th exon of the ATP4A gene (c.2107C>T) is responsible for an atypical familial type I gastric neuroendocrine tumour. PMID: 25678551
    6. ATP4A are found in nearly one-third of children with type 1 diabetes and more common among females. In this cross-sectional analysis, Hp infection was not associated with autoimmunity against parietal cells. PMID: 24773566
    7. Downregulation of ATP4A gene is associated with gastric cancer. PMID: 23317218
    8. Gastric H+/K+-ATPase activities are not associated with H pylori status in patients with chronic gastritis. PMID: 15962365
    9. study concludes that IL-1beta upregulates HKalpha transcription by inducing Sp1 binding to HKalpha Sp1 & NF-kappaB sites & that Helicobacter pylori perturbation of HKalpha expression is independent of Sp1-mediated basal HKalpha transcription PMID: 18772363
    10. cigarette smoke extract may cause an increase in the amount and activity of H,K-ATPase and smokers' susceptibility to development of peptic ulcer PMID: 19705497

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  • 亚细胞定位：
    Apical cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Cation transport ATPase (P-type) (TC 3.A.3) family, Type IIC subfamily
  • 组织特异性：
    Expressed in gastric parietal cells (at protein level).
  • 数据库链接：

    HGNC: 819

    OMIM: 137216

    KEGG: hsa:495

    STRING: 9606.ENSP00000262623

    UniGene: Hs.36992

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