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  4. Recombinant Human Poly (A) RNA polymerase, mitochondrial (MTPAP)

Recombinant Human Poly (A) RNA polymerase, mitochondrial (MTPAP)

  • 中文名称：
    人MTPAP重组蛋白
  • 货号：
    CSB-YP882118HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人MTPAP重组蛋白
  • 货号：
    CSB-EP882118HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人MTPAP重组蛋白
  • 货号：
    CSB-EP882118HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人MTPAP重组蛋白
  • 货号：
    CSB-BP882118HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人MTPAP重组蛋白
  • 货号：
    CSB-MP882118HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    MTPAP
  • Uniprot No.：
    Q9NVV4
  • 别名：
    0610027A18Rik; AW551379; EC 2.7.7.19; FLJ10486; mitochondrial; Mitochondrial poly(A) polymerase; mtPAP; PAP; PAP-associated domain-containing protein 1; PAPD1; PAPD1_HUMAN; Poly(A) RNA polymerase; Poly(A) RNA polymerase, mitochondrial; Poly(A) RNA polymerase, mitochondrial precursor; Polynucleotide adenylyltransferase; RP11-305E6.3; Terminal uridylyltransferase 1; TUTase 1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    38-582
  • 氨基酸序列
    KDL RRDEQPSGSV ETGFEDKIPK RRFSEMQNER REQAQRTVLI HCPEKISENK FLKYLSQFGP INNHFFYESF GLYAVVEFCQ KESIGSLQNG THTPSTAMET AIPFRSRFFN LKLKNQTSER SRVRSSNQLP RSNKQLFELL CYAESIDDQL NTLLKEFQLT EENTKLRYLT CSLIEDMAAA YFPDCIVRPF GSSVNTFGKL GCDLDMFLDL DETRNLSAHK ISGNFLMEFQ VKNVPSERIA TQKILSVLGE CLDHFGPGCV GVQKILNARC PLVRFSHQAS GFQCDLTTNN RIALTSSELL YIYGALDSRV RALVFSVRCW ARAHSLTSSI PGAWITNFSL TMMVIFFLQR RSPPILPTLD SLKTLADAED KCVIEGNNCT FVRDLSRIKP SQNTETLELL LKEFFEYFGN FAFDKNSINI RQGREQNKPD SSPLYIQNPF ETSLNISKNV SQSQLQKFVD LARESAWILQ QEDTDRPSIS SNRPWGLVSL LLPSAPNRKS FTKKKSNKFA IETVKNLLES LKGNRTENFT KTSGKRTIST QT
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but has higher activity with ATP and UTP (in vitro). Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. Might be responsible for the creation of some UAA stop codons which are not encoded in mtDNA.
  • 基因功能参考文献：
    1. Mitochondrial poly(A) polymerase is able to add the discriminator adenosine to tRNATyr. PMID: 26354863
    2. The polymerase activity of mtPAP is modulated by LRPPRC/SLIRP; N478D mtPAP mutation decreases its activity and the alteration in poly(A) length causes dysregulation of post-transcriptional expression and lack of respiratory chain complexes. PMID: 25008111
    3. Mutation of the MTPAP gene results in a cellular phenotype of increased DNA damage, reduced repair kinetics, increased cell death by apoptosis, and reduced clonogenic survival after exposure to ionizing radiation. PMID: 24651433
    4. show that dimerization is required for the catalytic activity of PAPD1 PMID: 21292163
    5. Characterization of this marker shows that it is orthologous to the human gene KIAA1462 located on HSA10p11.23, where a major quantitative trait locus for morbid obesity has been reported. PMID: 16810331
    6. Cloning of a human nuclear-encoded mitochondrial poly(A) polymerase (hmtPAP)that has a role in mitochondrial RNA processing. PMID: 15547249

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  • 相关疾病：
    Spastic ataxia 4, autosomal recessive (SPAX4)
  • 亚细胞定位：
    Cytoplasm. Mitochondrion.
  • 蛋白家族：
    DNA polymerase type-B-like family
  • 组织特异性：
    Ubiquitous, with stronger expression in tissues with high energy requirements: heart, brain, and skeletal muscle.
  • 数据库链接：

    HGNC: 25532

    OMIM: 613669

    KEGG: hsa:55149

    STRING: 9606.ENSP00000263063

    UniGene: Hs.173946

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