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  4. Recombinant Human Pleckstrin homology domain-containing family H member 2 (PLEKHH2), partial

Recombinant Human Pleckstrin homology domain-containing family H member 2 (PLEKHH2), partial

  • 中文名称：
    人PLEKHH2重组蛋白
  • 货号：
    CSB-YP814208HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PLEKHH2重组蛋白
  • 货号：
    CSB-EP814208HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PLEKHH2重组蛋白
  • 货号：
    CSB-EP814208HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PLEKHH2重组蛋白
  • 货号：
    CSB-BP814208HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PLEKHH2重组蛋白
  • 货号：
    CSB-MP814208HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PLEKHH2
  • Uniprot No.：
    Q8IVE3
  • 别名：
    KIAA2028; PKHH2_HUMAN; Pleckstrin homology domain containing family H member 2; Pleckstrin homology domain-containing family H member 2; Pleckstrin homology MyTH4 and FERM domain containing H2; PLEKHH1L; Plekhh2; PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia.
  • 基因功能参考文献：
    1. Suggest a structural and functional role for Plekhh2 in the podocyte foot processes. PMID: 22832517
    2. PLEKHH2, which has mRNA and protein expression exclusively in the glomerulus, may be a genetic risk factor for susceptibility to diabetic nephropathy in the diabetic population PMID: 18752002
  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Note=Localizes to foot process of podocytes. Localization to peripheral regions of lamellipodia seems to be dependent on PI3K.
  • 组织特异性：
    Kidney. Reduced expression in patients with focal segmental glomerulosclerosis.
  • 数据库链接：

    HGNC: 30506

    OMIM: 612723

    KEGG: hsa:130271

    STRING: 9606.ENSP00000282406

    UniGene: Hs.164162

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