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  4. Recombinant Human Platelet-activating factor acetylhydrolase 2, cytoplasmic (PAFAH2)

Recombinant Human Platelet-activating factor acetylhydrolase 2, cytoplasmic (PAFAH2)

  • 中文名称：
    人PAFAH2重组蛋白
  • 货号：
    CSB-YP857448HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PAFAH2重组蛋白
  • 货号：
    CSB-EP857448HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PAFAH2重组蛋白
  • 货号：
    CSB-EP857448HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PAFAH2重组蛋白
  • 货号：
    CSB-BP857448HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PAFAH2重组蛋白
  • 货号：
    CSB-MP857448HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PAFAH2
  • Uniprot No.：
    Q99487
  • 别名：
    PAFAH2Platelet-activating factor acetylhydrolase 2; cytoplasmic; EC 3.1.1.47; Serine-dependent phospholipase A2; SD-PLA2; hSD-PLA2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-392
  • 氨基酸序列
    MGVNQSVGFP PVTGPHLVGC GDVMEGQNLQ GSFFRLFYPC QKAEETMEQP LWIPRYEYCT GLAEYLQFNK RCGGLLFNLA VGSCRLPVSW NGPFKTKDSG YPLIIFSHGL GAFRTLYSAF CMELASRGFV VAVPEHRDRS AATTYFCKQA PEENQPTNES LQEEWIPFRR VEEGEKEFHV RNPQVHQRVS ECLRVLKILQ EVTAGQTVFN ILPGGLDLMT LKGNIDMSRV AVMGHSFGGA TAILALAKET QFRCAVALDA WMFPLERDFY PKARGPVFFI NTEKFQTMES VNLMKKICAQ HEQSRIITVL GSVHRSQTDF AFVTGNLIGK FFSTETRGSL DPYEGQEVMV RAMLAFLQKH LDLKEDYNQW NNLIEGIGPS LTPGAPHHLS SL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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PAFAH2 antibodies

靶点详情

  • 功能：
    Catalyzes the hydrolyze of the acetyl group at the sn-2 position of platelet-activating factor (PAF) and its analogs, leading to their inactivation. Hydrolyzes propionyl and butyroyl moieties approximately half as effectively as PAF. Also catalyzes transacetylation of the acetyl group from platelet-activating factor (PAF) to lysoplasmalogen and to sphingosine, producing plasmalogen analogs of PAF and N-acetylsphingosine (C2-ceramide) respectively. Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position.
  • 基因功能参考文献：
    1. Data show that the activity of plasma platelet activating factor acetylhydrolase (PAF-AH) increases in parallel with diabetic retinopathy (DR) severity. PMID: 26791393
    2. The oligomeric state of PAFAH-II drives functional protein trafficking. PAFAH-II localization to the membrane is critical for substrate acquisition and effective oxidative stress protection. PMID: 25707358
    3. presence of platelet-activating factor acetylhydrolase II in a restricted pattern in human skin; it is involved in protecting this organ against oxidative stress through the degradation of oxidatively modified bioactive phospholipids. PMID: 12406338
    4. Lp-PLA2 was higher in those with more extensive Coronary artery disease PMID: 17157859
    5. PAF-AH II exerts strong neuroprotective effects against ischemic injury: the neurological deficit scores, cerebral edema index, and relative infarction volume are all significantly lower in PAFAH2 transgenic mice than in wild-type mice. PMID: 17272759
    6. examines substrate specificity for intracellular and plasma PAF-AHs PMID: 11294621

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  • 亚细胞定位：
    Cytoplasm. Membrane; Lipid-anchor. Endoplasmic reticulum membrane; Lipid-anchor.
  • 蛋白家族：
    Serine esterase family
  • 组织特异性：
    Broadly expressed in different tissues, but high in B- and T-lymphocytes. In brain, expression is restricted to amygdala and frontal cortex.
  • 数据库链接：

    HGNC: 8579

    OMIM: 602344

    KEGG: hsa:5051

    STRING: 9606.ENSP00000363400

    UniGene: Hs.477083

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