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  4. Recombinant Human Plasma membrane calcium-transporting ATPase 1 (ATP2B1), partial

Recombinant Human Plasma membrane calcium-transporting ATPase 1 (ATP2B1), partial

  • 中文名称：
    Recombinant Human Plasma membrane calcium-transporting ATPase 1(ATP2B1) ,partial
  • 货号：
    CSB-YP002335HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Plasma membrane calcium-transporting ATPase 1(ATP2B1) ,partial
  • 货号：
    CSB-EP002335HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Plasma membrane calcium-transporting ATPase 1(ATP2B1) ,partial
  • 货号：
    CSB-EP002335HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Plasma membrane calcium-transporting ATPase 1(ATP2B1) ,partial
  • 货号：
    CSB-BP002335HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Plasma membrane calcium-transporting ATPase 1(ATP2B1) ,partial
  • 货号：
    CSB-MP002335HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ATP2B1
  • Uniprot No.：
    P20020
  • 别名：
    AT2B1_HUMAN; ATP2B1; ATPase Ca++ transporting plasma membrane 1; Plasma membrane calcium ATPase 1; Plasma membrane calcium ATPase isoform 1; Plasma membrane calcium pump isoform 1; Plasma membrane calcium transporting ATPase 1; Plasma membrane calcium-transporting ATPase 1; PMCA 1; PMCA1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-induced calcium oscillations in preosteoclasts and mediating calcium extrusion in mature osteoclasts. Regulates insulin sensitivity through calcium/calmodulin signaling pathway by regulating AKT1 activation and NOS3 activation in endothelial cells. May play a role in synaptic transmission by modulating calcium and proton dynamics at the synaptic vesicles.
  • 基因功能参考文献：
    1. Cryoelectron microscopy reveals the PMCA1 structure in complex with neuroplastin. PMID: 30190470
    2. people with the major allele of ATP2B1 rs17249754 are susceptible to hypertension especially in low intake of Ca and high ratio of Na and K PMID: 28934190
    3. Crossover analysis and stratified analysis indicated that BMI has a major effect on the development of hypertension, while ATP2B1 variants have a minor effect PMID: 26933664
    4. Excessive sodium intake significantly modified the risk of developing Hypertension associated with ATP2B1 rs17249754 genetic trait. Homozygote carriers may be at higher risk of hypertension, when they consume excessive sodium intake. PMID: 27149052
    5. Data show that plasma membrane Ca(2+)-ATPase (PMCA) was associated with tubulin in normotensive and hypertensive erythrocytes. PMID: 26307527
    6. rs11105378 near ATP2B1 was associated with increased systolic and diastolic blood pressure in a Chinese population. PMID: 25618516
    7. ATP2B1 rs12817819 A allele is associated with increased risk for drug resistant hypertension. PMID: 25385345
    8. While PMCA1b has a housekeeping function in colon cancer cells, PMCA4b participates in the reorganization of the calcium signaling machinery during cell differentiation. PMID: 26116539
    9. Report that ATP2B1 rs2681472 is associated with early-onset preeclampsia in Northern Han Chinese women. PMID: 24642721
    10. An increase of phosphatidylcholine/detergent molar ratio leads to a biphasic behavior of the PMCA Ca2+-ATPase activity, whose maximum depends on phosphatidylcholine characteristics. PMID: 25605721
    11. The present study confirmed the significant association of ATP2B1 rs17249754 with risk of hypertension among Chinese children. PMID: 23759979
    12. The downregulation of PMCA1 and the disruption of calcium homeostasis may play important roles in UVB-induced HLE B-3 cell apoptosis. PMID: 23817774
    13. analysis of how human plasma membrane Ca2+ pump PMCA h4xb is hyperactivated by mutation of Glu99 to Lys PMID: 24584935
    14. Association of the ATP2B1 gene and susceptibility to hypertension, blood pressure traits and carotid-femoral pulse wave velocities in a Chinese population. PMID: 23079715
    15. Polymorphism near the ATP2B1 gene is associated with hypertension risk in East Asians. PMID: 22229515
    16. The authors provide data revealing both functional and physical links between the activation of stromal interacting molecule 1 (STIM1) and PMCA-mediated Ca(2+) clearance. PMID: 22246182
    17. Immunohistochemical analysis of the distribution of TRPV6 and PMCA1 in the uterus revealed that both proteins are abundantly expressed in the cytoplasm of endometrial and glandular epithelial cells during menstrual phases. PMID: 21400627
    18. Cloned the C-terminal domain of the human PMCA isoform 1b, and characterized its properties in solution. The expressed protein maintains its tendency to oligomerize in aqueous solutions, but it is dissociated by amphipathic molecules. PMID: 21126504
    19. Observational study and meta-analysis of gene-disease association. (HuGE Navigator) PMID: 21045733
    20. this study confirmed common genetic variation in ATP2B1 to be associated with blood pressure levels and risk of hypertension PMID: 20921432
    21. Consistent genetic factors for ATP2B1, CSK, ARSG and CSMD1 were present, which have been shown to be associated with high blood pressure and hypertension in two Korean cohorts. PMID: 19960030
    22. The transmembrane domain of the PMCA undergoes major rearrangements resulting in altered lipid accessibility upon Ca(2+) binding and activation. PMID: 19892708
    23. Data show that in the presence of plasma membrane Ca(2+) ATPase inhibitors, locally-released Ca(2+) propagates from one cell to another, indicating that Ca(2+) was self-amplified to mediate intercellular Ca(2+) waves. PMID: 19840794
    24. Plasma membrane Ca2+ ATPase isoform 2b interacts preferentially with Na+/H+ exchanger regulatory factor 2 in apical plasma membranes PMID: 11786550
    25. role in the intracellular Ca(2+) extrusion of syncytiotrophoblast-like structure originating from the differentiation of cultured trophoblast cells isolated from human term placenta PMID: 12784250
    26. PMCA1 has a high sensitivity to degradation by calpain PMID: 12851406
    27. modulation of PMCA has important effects in regulating the proliferation of human breast cancer MCF-7 cells, involving changes in cell cycle kinetics but not cell cycle arrest PMID: 15911623
    28. Inactivation of the PMCA1 gene is a frequent and early event during oral carcinogenesis, and gene expression may be regulated by an epigenetic mechanism. PMID: 16328033
    29. PMCA activity is influenced by membrane lipid composition and structure. The naturally high degree of lipid order in plasma membranes such as those found in human lens may serve to support PMCA activity. PMID: 16412504
    30. Alterations in the region of the alternative splicing site A change the sensitivity to Ca(2+) of the human isoform 4 of the PMCA. PMID: 16488415
    31. PMCA1 is shown to be present in the human syncytiotrophoblast homogenate. PMID: 18657858
    32. PMCA is the main mechanism involved in Ca(2+) efflux in ECV 304 cells. PMID: 18929409
    33. Muscarinic-induced recruitment of plasma membrane Ca2+-ATPase involves PSD-95/Dlg/Zo-1-mediated interactions. PMID: 19017653
    34. These results indicate that in intact cells the Ca(2+) pump is protected from glycation-induced inactivation. PMID: 19070897
    35. Data show that the calcium dependencies of intracellular Ca(2+)-ATPase (SERCA and SPCA) activity are the same in human Alzheimer disease and normal brain but that of plasma membrane Ca(2+)-ATPase (PMCA) is different. PMID: 19144698
    36. Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 19430479
    37. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 19396169

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Basolateral cell membrane. Cell junction, synapse. Cell junction, synapse, presynaptic cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Cation transport ATPase (P-type) (TC 3.A.3) family, Type IIB subfamily
  • 组织特异性：
    Isoform B: Ubiquitously expressed. Isoform C: Found in brain cortex, skeletal muscle and heart muscle. Isoform D: Has only been found in fetal skeletal muscle. Isoform K: Found in small intestine and liver. Abundantly expressed in the endometrial epitheli
  • 数据库链接：

    HGNC: 814

    OMIM: 108731

    KEGG: hsa:490

    STRING: 9606.ENSP00000261173

    UniGene: Hs.506276

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