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  4. Recombinant Human Phosphofurin acidic cluster sorting protein 1 (PACS1), partial

Recombinant Human Phosphofurin acidic cluster sorting protein 1 (PACS1), partial

  • 中文名称：
    人PACS1重组蛋白
  • 货号：
    CSB-YP017371HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PACS1重组蛋白
  • 货号：
    CSB-EP017371HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PACS1重组蛋白
  • 货号：
    CSB-EP017371HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PACS1重组蛋白
  • 货号：
    CSB-BP017371HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PACS1重组蛋白
  • 货号：
    CSB-MP017371HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PACS1
  • Uniprot No.：
    Q6VY07
  • 别名：
    Cytosolic sorting protein PACS1; PACS 1; PACS-1; Pacs1; PACS1_HUMAN; Phosphofurin acidic cluster sorting protein 1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

相关产品

PACS1 antibodies

靶点详情

  • 功能：
    Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN.
  • 基因功能参考文献：
    1. Using whole exome sequencing (WES), we identified eight additional individuals with the same p.Arg203Trp missense variant in PACS1 that we demonstrated were de novo in seven individuals with available parental DNA. PMID: 28111752
    2. PCAF and ADA3 transcriptionally regulate PACS1 and PACS1 is a key regulator of BAX/BAK oligomerization and the intrinsic (mitochondrial) pathway to apoptosis. PMID: 28060382
    3. Protein adaptation and the expanding roles of the PACS1 and PACS2 proteins in tissue homeostasis and disease has been summarized. (Review) PMID: 28476937
    4. study showed for the first time that the rs564343 in phosphofurin acidic cluster sorting protein 1(PACS1) was associated with risk of severe obesity in Chinese children PMID: 28564656
    5. Clinical description of the PACS1-related syndrome has been reported in 19 unrelated patients. PMID: 26842493
    6. PACS1 plays an important role in protein sorting for amyloidogenic-burden control via both SORLA-dependent and SORLA-independent mechanisms. PMID: 24001769
    7. Single nucleotide polymorphisms in PAKS1 gene is associated with obesity. PMID: 23563609
    8. Our findings suggest that PACS1 is necessary for the formation of craniofacial structures and that perturbation of its functions results in a specific syndromic ID phenotype. PMID: 23159249
    9. The sites on Nef and the PACS proteins required for their interaction, are identified. PMID: 22496420
    10. PACS-1 along with HIV-1 nef, has a role in downregulating cell surface MHC-I to the trans-Golgi network and usurping the ARF6 endocytic pathway PMID: 12526811
    11. subcellular localization and function of polycystin-2 are directed by phosphofurin acidic cluster sorting protein (PACS)-1 and PACS-2 PMID: 15692563
    12. casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia PMID: 16308564
    13. CK2-activated phosphorylation cascade controlling PACS-1- and GGA3-mediated CI-MPR sorting, is reported. PMID: 16977309
    14. PACS-1 mediates phosphorylation-dependent ciliary trafficking of the CNGB1b in olfactory sensory neurons. PMID: 19710307

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  • 相关疾病：
    Schuurs-Hoeijmakers syndrome (SHMS)
  • 亚细胞定位：
    Golgi apparatus, trans-Golgi network.
  • 蛋白家族：
    PACS family
  • 数据库链接：

    HGNC: 30032

    OMIM: 607492

    KEGG: hsa:55690

    STRING: 9606.ENSP00000316454

    UniGene: Hs.644326

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