Recombinant Human Phosphatidate phosphatase LPIN1 (LPIN1), partial

1. Normal human adipose tissue functions and differentiation has been found in rhabdomyolysis patients with biallelic LPIN1 inactivating mutations. PMID: 28986436
2. conclude that Lipin-1 can antagonize HSC activation through the inhibition of TGF-beta/SMAD signaling and that resveratrol may affect Lipin-1 gene induction and contribute to the inhibition of TGF-beta-mediated hepatic fibrogenesis PMID: 27345520
3. beta-TRCP depletion in HepG2 hepatocellular carcinoma cells resulted in increased Lipin1 protein abundance. PMID: 28049764
4. This study showed that LPIN1 knockdown blocks phospholipid synthesis and changes membrane lipid compositions, and that lipin-1 knockdown significantly inhibits tumor growth in vivo using an orthotopic xenograft breast mouse model. PMID: 28347999
5. The novel insights into the regulation of human Lipin-1 stability will be useful in planning further studies to elucidate its metabolic processes. PMID: 28483528
6. It seems that a new signaling axis, SIRT1-SFRS10-LPIN1 axis, acting in the pathogenesis of alcoholic fatty liver disease exists. PMID: 28467182
7. Consistent with these observations, LPIN1 levels were positively correlated with IRS1 expression in human breast cancer. Thus, our results indicate a mechanism by which IRS1 expression is increased in breast cancer, and LPIN1 may be a promising drug target for anticancer therapy PMID: 27729374
8. LPIN1 is upregulated in non-alcoholic fatty liver disease. Up-regulation of miR-122 can trigger the compensatory response of LPIN1 and CTDNEP1 in hepatosteatosis. PMID: 28287811
9. lipin-1-mediated downregulation of p21 is critical for the progress of keratinocyte differentiation PMID: 26658689
10. lipin-1 has a critical role in the regulation of macrophage inflammatory responses to modified-LDL PMID: 26288136
11. Results of our study suggest that rs2716610: C>T polymorphism of LPIN1 gene could have a protective effect against development of metabolic syndrome, while rs11693809: C>T might affect a glucose control in patients with MS. PMID: 26276647
12. Lipin-1 controls main cellular processes involved in cancer progression and that its targeting, alone or in combination with other treatments, could open new avenues in anticancer therapy. PMID: 25834103
13. Lipin1beta might play a role in the pathogenesis of insulin resistance in gestational diabetes mellitus PMID: 25974997
14. LPIN1 plays a functional role in lipid synthesis and storage, a role which is highly conserved from human to yeast. PMID: 25475986
15. the lipin-1 N-terminal domain is important for its catalytic activity, nuclear localization, and binding to PP-1cgamma PMID: 24558042
16. Lipin-1 deficiency is associated with lipid metabolism alterations resulting in massive rhabdomyolysis. PMID: 23928362
17. the SNP in the LPIN1 gene (rs10192566) had no effect on the trough rosiglitazone steady-state concentration. PMID: 23426382
18. Phosphorylation of lipin 1 and charge on the phosphatidic acid head group control its phosphatidic acid phosphatase activity and membrane association PMID: 23426360
19. Data suggests common single nucleotide polymorphisms within the LPIN1 region were associated with Type 2 diabetes and metabolic traits in the Chinese population. PMID: 22853689
20. LPIN1-related myolysis constitutes a major cause of early-onset rhabdomyolysis and occasionally in adults. Heterozygous LPIN1 mutations may cause mild muscular symptoms. No major defects of LPIN2 or LPIN3 genes were associated with muscle manifestations. PMID: 22481384
21. We conclude that direct control of lipin 1 transcription by HIF-1 is an important regulatory feature of lipid metabolism and its adaptation to hypoxia. PMID: 22467849
22. Lipin1 rs13412852 single nucleotide polymorphism is associated with the severity of liver damage and fibrosis progression in pediatric patients with histological NAFLD. PMID: 22157924
23. LPIN1 mutations should be considered in any child presenting with severe rhabdomyolysis. PMID: 22480698
24. Estrogen-related receptor gamma (ERRgamma) is a novel transcriptional regulator of phosphatidic acid phosphatase, LIPIN1, and inhibits hepatic insulin signaling PMID: 21911493
25. reduced expression of SFRS10, as observed in tissues from obese humans, alters LPIN1 splicing, induces lipogenesis, and therefore contributes to metabolic phenotypes associated with obesity. PMID: 21803291
26. Lpin1 expression in response to nutritional stress is controlled through the reactive oxygen species-ATM-p53 pathway. PMID: 22055193
27. The aim of present study was to investigate for the first time the association of lipin 1 gene polymorphisms with metabolic and hormonal profile in polycystic ovary syndrome patients and controls. PMID: 21448847
28. PPARG and LPIN1 gene polymorphisms role of these genes in lipid metabolism and pathogenesis of type 2 diabetes and metabolic syndrome PMID: 21263402
29. lipin-1gamma is the main lipin-1 isoform expressed in normal human brain, suggesting a specialized role in regulating brain lipid metabolism. PMID: 21616074
30. data suggest that lipin-1 associates with lipid droplets and regulates the activation of cytosolic group IVA phospholipase A(2)alpha in monocyte-derived macrophages PMID: 21478406
31. dullard shows specificity for the peptide corresponding to the insulin-dependent phosphorylation site (Ser106) of lipin PMID: 21413788
32. Data revealed that lipin 1 formed stable homo-oligomers with itself and hetero-oligomers with lipin 2/3. PMID: 20735359
33. Results showed a marked association between LPIN1 and PPARalpha gene expression both in subcutaneous and visceral adipose tissues and might suggest a possible role of LPIN1 in stress conditions that occur in chronic obesity and underlie insulin resistance PMID: 20101248
34. Data suggest that the high frequency of the intragenic LPIN1 deletion should provide a valuable criterion for fast diagnosis, prior to muscle biopsy. PMID: 20583302
35. the low-grade proinflammatory environment and the insulin resistance associated with obesity may contribute to downregulate LPIN1 in adipose tissue PMID: 20530740
36. LPIN1 rs33997857, rs6744682, and rs6708316 did not associate with type 2 diabetes, obesity, or related quantitative metabolic phenotypes in the Danish population examined. PMID: 20356931
37. the LPIN1 gene seemed not to be a major susceptibility gene for type 2 diabetes or related metabolic phenotypes in the Chinese population. PMID: 19543209
38. sumoylation facilitates the nuclear localization and transcriptional coactivator behavior of lipin-1alpha, which may act as a sumoylation-regulated transcriptional coactivator in brain PMID: 19753306
39. LPIN1 mutations are not commonly seen in patients with lipodystrophy who had no mutations in known disease genes. PMID: 12111372
40. effects of genetic variation in lipin levels on glucose homeostasis across species by analyzing lipin transcript levels in human and mouse adipose tissues PMID: 16357106
41. human lipin 1 is a Mg2+-dependent PA phosphatase, the penultimate enzyme in the pathway to synthesize triacylglyerol PMID: 16467296
42. These results suggest that increased adipogenesis and/or lipogenesis in subcutaneous fat, mediated by the LPIN1 gene, may prevent lipotoxicity in muscle, leading to improved insulin sensitivity PMID: 17003347
43. Body fat accumulation is a major regulator of human adipose LPIN1 expression and suggests a role of LPIN1 in human preadipocyte as well as mature adipocyte function. PMID: 17035674
44. insulin and epinephrine control lipin primarily by changing localization rather than intrinsic PAP activity PMID: 17105729
45. Lipin 1beta and overexpression of peroxisome proliferator-activated receptor-gamma coactivator (PGC)-1alpha are downregulated by obesity and obesity-related metabolic perturbations in human subjects. PMID: 17563064
46. Variants of the LPIN1 gene have significant effects in human metabolic traits and implicate lipin in the pathophysiology of the metabolic syndrome. PMID: 17940119
47. LPIN1 messenger RNA levels positively correlated with insulin sensitivity in all subjects with obesity, NIDDM, and HIV-associated lipodystrophy PMID: 17950103
48. Sequence variation in the LPIN1 gene contributes to variation in resting metabolic rate and obesity-related phenotypes potentially in an age-dependent manner. PMID: 18070763
49. Lpin1 glucocorticoid response element binds to the glucocorticoid receptor PMID: 18362392
50. Study provides further evidence that lipin 1 may play a role in blood pressure regulation, especially in men. PMID: 18437145

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HGNC: 13345

OMIM: 268200

KEGG: hsa:23175

STRING: 9606.ENSP00000256720

UniGene: Hs.467740