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  4. Recombinant Human Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PPRC1), partial

Recombinant Human Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PPRC1), partial

  • 中文名称：
    人PPRC1重组蛋白
  • 货号：
    CSB-YP733159HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PPRC1重组蛋白
  • 货号：
    CSB-EP733159HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PPRC1重组蛋白
  • 货号：
    CSB-EP733159HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PPRC1重组蛋白
  • 货号：
    CSB-BP733159HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PPRC1重组蛋白
  • 货号：
    CSB-MP733159HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PPRC1
  • Uniprot No.：
    Q5VV67
  • 别名：
    PPRC1; KIAA0595; Peroxisome proliferator-activated receptor gamma coactivator-related protein 1; PGC-1-related coactivator; PRC
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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PPRC1 antibodies

靶点详情

  • 功能：
    Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes.
  • 基因功能参考文献：
    1. PRC and c-MYC can act in concert through Akt-GSK-3 signaling to reprogram gene expression in response to mitochondrial stress. PMID: 27789709
    2. PRC is a negative regulator of endothelial inflammation; it negatively regulates endothelial adhesion of monocytes via inhibition of NF kappaB activity PMID: 23954632
    3. A general role for PRC in the adaptive response to cellular dysfunction. PMID: 23364789
    4. PRC has a role in the rapid modulation of metabolic functions in response to the status of the cell cycle PMID: 19956726
    5. overexpression of the PRC pathway is responsible for mitochondrial proliferation in the context of thyroid oncocytoma PMID: 14550271
    6. PGC-1 has a role in regulating gluconeogenic genes along with HNF-4alpha and SREBP-1 PMID: 14722127
    7. This review focuses on the biologic and physiologic functions of the PGC-1 coactivators, with particular emphasis on striated muscle, liver, and other organ systems relevant to common diseases such as diabetes and heart failure. PMID: 16511594
    8. Upregulation of PGC-1alpha and PGC-1beta in the colorectal tumor cells can be part of an adaptation mechanism to help overcome the severe consequences of mtDNA mutations on oxidative phosphorylation. PMID: 17341490
    9. These results revealed that bile acid inhibits the promoter activity of PGC-1 in an SHP-dependent manner. PMID: 17390079
    10. Activation of the SIRT1/PGC-1 pathway, in a metabolic context promotes mitochondrial function and this pathway plays a role in neurodegerative disease. Review. PMID: 17937892
    11. The results are consistent with a pathway whereby PRC regulates NRF-2-dependent genes through a multiprotein complex involving HCF-1. PMID: 18343819
    12. support a role for PRC in the integration of pathways directing mitochondrial respiratory function and cell growth PMID: 19036724
    13. Coordinate regulation of nucleus-encoded mitochondrial transcription factors by NRFs and PGC-1 family coactivators is essential to the control of mitochondrial biogenesis PMID: 15684387

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Strongly expressed in heart and skeletal muscle, moderately in lung, placenta, intestine, liver, kidney, spleen, thymus, colon and brain. Also expressed in several oncocytic thyroid tumors.
  • 数据库链接：

    HGNC: 30025

    OMIM: 617462

    KEGG: hsa:23082

    STRING: 9606.ENSP00000278070

    UniGene: Hs.533551

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