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  4. Recombinant Human Periplakin (PPL), partial

Recombinant Human Periplakin (PPL), partial

  • 中文名称：
    人PPL重组蛋白
  • 货号：
    CSB-YP018488HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PPL重组蛋白
  • 货号：
    CSB-EP018488HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PPL重组蛋白
  • 货号：
    CSB-EP018488HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PPL重组蛋白
  • 货号：
    CSB-BP018488HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PPL重组蛋白
  • 货号：
    CSB-MP018488HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PPL
  • Uniprot No.：
    O60437
  • 别名：
    190 kDa paraneoplastic pemphigus antigen; 195 kDa cornified envelope precursor; 195 kDa cornified envelope precursor protein; AW553870; KIAA0568; MGC134872 ; PEPL_HUMAN; Periplakin; ppl
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling.
  • 基因功能参考文献：
    1. Letter: suggest periplakin autoimmunity may be involved in asthma pathogenesis. PMID: 27717390
    2. PPL overexpression inhibited the growth of colon cancer. PMID: 28068625
    3. Low serum periplakin is associated with urothelial carcinoma. PMID: 25520130
    4. Human gamma-delta T cells are activated by cytosolic interactions of BTN3A1 with soluble phosphoantigens and the cytoskeletal adaptor periplakin. PMID: 25637025
    5. Loss of periplakin expression is associated with pathological stage and cancer-specific survival in patients with urothelial carcinoma of the urinary bladder. PMID: 24942859
    6. Annexin A9 and periplakin co-localise in the epidermis and annexin A9 is up-regulated in differentiating keratinocytes, but the epidermal annexin A9 expression does not require periplakin. PMID: 22841549
    7. involved in cellular movement and attachment in pharyngeal squamous cancer cells PMID: 21951621
    8. Sciellin, SPRR3, and periplakin transcripts were all upregulated (4.67-, 4.95-, 2.77-fold, respectively) by prolonged exposure to cyclic strain (24-72 h), but not at earlier time points. PMID: 19211270
    9. autoantibodies are detected in patients with paraneoplastic pemphigus PMID: 18820940
    10. This protein binds to protein kinase B. PMID: 12244133
    11. in spite of its high homology and structural similarity with envoplakin, periplakin is functionally closer to the plakin proteins plectin and desmoplakin, and may function tissue-wide as a scaffolding protein in intermediate filament assembly PMID: 12366696
    12. interactions between helix VIII of the human mu-opioid receptors and the C terminus of periplakin disrupt G protein activation PMID: 12810704
    13. envoplakin and periplakin bind to the plasma membrane upon elevation of intracellular [Ca(2+)] in differentiating keratinocytes, where they serve as a scaffold for cornified cell envelope assembly PMID: 15033990
    14. periplakin (PPL) as a selective interacting protein for the intracellular tail of FcgammaRI but no other activatory FcRs PMID: 15229321
    15. the involvement of desmoplakin (DP), plectin, and periplakin in the destruction of epithelial cell integrity ensures the efficient elimination of cytoskeleton, but also provides specificity for selectively targeting individual adhesion molecules PMID: 15500642
    16. Periplakin interferes with G protein activation by the melanin-concentrating hormone receptor-1 by binding to the proximal segment of the receptor C-terminal tail PMID: 15590649
    17. caspase 6 cleaves periplakin at an unconventional recognition site, amino acid sequence TVAD PMID: 15654952
    18. Downregulation of periplakin is associated with esophageal squamous cell carcinoma PMID: 16400690
    19. A novel functional co-localisation is identified between two plakin cytolinker proteins. PMID: 17662978

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  • 亚细胞定位：
    Cell junction, desmosome. Cytoplasm, cytoskeleton. Cell membrane. Cytoplasm.
  • 蛋白家族：
    Plakin or cytolinker family
  • 组织特异性：
    Expressed in stratified squamous epithelia and in some other epithelia.
  • 数据库链接：

    HGNC: 9273

    OMIM: 602871

    KEGG: hsa:5493

    STRING: 9606.ENSP00000340510

    UniGene: Hs.192233

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