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  4. Recombinant Human Nucleosome-remodeling factor subunit BPTF (BPTF), partial

Recombinant Human Nucleosome-remodeling factor subunit BPTF (BPTF), partial

  • 中文名称：
    Recombinant Human Nucleosome-remodeling factor subunit BPTF(BPTF) ,partial
  • 货号：
    CSB-YP614258HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Nucleosome-remodeling factor subunit BPTF(BPTF) ,partial
  • 货号：
    CSB-EP614258HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Nucleosome-remodeling factor subunit BPTF(BPTF) ,partial
  • 货号：
    CSB-EP614258HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Nucleosome-remodeling factor subunit BPTF(BPTF) ,partial
  • 货号：
    CSB-BP614258HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Nucleosome-remodeling factor subunit BPTF(BPTF) ,partial
  • 货号：
    CSB-MP614258HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    BPTF
  • Uniprot No.：
    Q12830
  • 别名：
    BPTF; BPTF_HUMAN; Bromodomain and PHD finger containing transcription factor; Bromodomain and PHD finger-containing transcription factor; Bromodomain PHD finger transcription factor; FAC 1; fac1; FALZ; Fetal Alz 50 clone 1 protein; Fetal Alz 50 reactive clone 1; Fetal Alz-50 clone 1 protein; Fetal Alzheimer antigen; Nucleosome remodeling factor; Nucleosome remodeling factor subunit BPTF; Nucleosome remodeling factor, large subunit; Nucleosome-remodeling factor subunit BPTF; NURF 301; NURF301
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex. Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development. Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes. Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent. May also regulate transcription through direct binding to DNA or transcription factors.
  • 基因功能参考文献：
    1. Haploinsufficiency of BPTF gene is associated with Syndromic Developmental and Speech Delay, Postnatal Microcephaly, and Dysmorphic Features. PMID: 28942966
    2. Two new signals were observed at genome-wide significance (P < 5 x 10-8), namely, rs7216064 (17q24.3, BPTF), for overall lung adenocarcinoma risk, and rs3817963 (6p21.3, BTNL2) which is specific to cases with EGFR mutations. In further sub-analyses by EGFR status, rs9387478 (ROS1/DCBLD1) and rs2179920 (HLA-DPB1) showed stronger estimated associations in EGFR-positive compared to EGFR-negative cases PMID: 28025329
    3. NRP2 inhibits WDFY1 transcription by preventing the nuclear localization of a transcription factor, Fetal ALZ50-reactive clone 1 (FAC1). PMID: 27026195
    4. Overexpression of BPTF is associated with melanoma cell survival and progression. PMID: 27185926
    5. somatic frameshift mutations of BPTF were present in gastric cancer and colorectal cancers PMID: 26899553
    6. BPTF plays an essential role in cell growth and survival by targeting multiply signaling pathways in human lung cancers PMID: 26418899
    7. High BPTF expression was significantly correlated with tumor progression and may be a potent prognostic marker of colorectal cancer. PMID: 25716692
    8. expression may be marker for survival prediction in hepatocellular carcinoma PMID: 25362514
    9. The PHD-adjacent bromodomain in BPTF binds with marked selectivity H4K16ac, in combination with H3K4me3 at the mononucleosome level. PMID: 21596426
    10. the novel translocation breakpoint within the BPTF gene is associated with a pre-malignant phenotype PMID: 20300178
    11. hkelch-like ECH-associated protein 1 regulates FAC1 in addition to its known role in control of Nrf2 PMID: 15379550
    12. These findings suggest a role for FAC1 in apoptosis following release of Nrf2 from Keap1 in response to oxidative stress. PMID: 16137655
    13. crystallographic and NMR structures of the bromodomain-proximal PHD finger of BPTF in free and H3(1-15)K4me3-bound states PMID: 16728978
    14. High FALZ expression is associated with metastatic spread to the brain in primary non-small cell lung cancer. PMID: 19190132

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Note=In brains of Alzheimer disease patients, present in a subset of amyloid-containing plaques.
  • 蛋白家族：
    PBTF family
  • 组织特异性：
    Ubiquitously expressed, with highest levels in testis. Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex (at protein level).
  • 数据库链接：

    HGNC: 3581

    OMIM: 601819

    KEGG: hsa:2186

    STRING: 9606.ENSP00000307208

    UniGene: Hs.444200

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