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  4. Recombinant Human Nuclear pore complex protein Nup214 (NUP214), partial

Recombinant Human Nuclear pore complex protein Nup214 (NUP214), partial

  • 中文名称：
    人NUP214重组蛋白
  • 货号：
    CSB-YP016197HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人NUP214重组蛋白
  • 货号：
    CSB-EP016197HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人NUP214重组蛋白
  • 货号：
    CSB-EP016197HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人NUP214重组蛋白
  • 货号：
    CSB-BP016197HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人NUP214重组蛋白
  • 货号：
    CSB-MP016197HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    NUP214
  • Uniprot No.：
    P35658
  • 别名：
    214 kDa nucleoporin; CAIN; CAN; CAN protein putative oncogene; D9S46E; N214; NU214_HUMAN; Nuclear pore complex protein Nup214; nucleoporin 214kDa; Nucleoporin Nup214; Nup214; p250; Protein CAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Part of the nuclear pore complex. Has a critical role in nucleocytoplasmic transport. May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.; (Microbial infection) Required for capsid disassembly of the human adenovirus 5 (HadV-5) leading to release of the viral genome to the nucleus (in vitro).
  • 基因功能参考文献：
    1. SQSTM1-Nup214, although mostly cytoplasmic, also forms nuclear bodies and inhibits nuclear protein but not poly(A)(+) RNA export. PMID: 27613868
    2. We have identified NUP214, a member of the massive nuclear pore complex, as a novel miR-133b target. PMID: 25743594
    3. Both in vitro hexon binding and in vivo nuclear import of the adenovirus genome were strongly reduced in Nup214-depleted cells suggesting that Nup214 is a major binding site of adenovirus during infection. PMID: 25410864
    4. NUP214-ABL1-mediated cell proliferation in T-cell acute lymphoblastic leukemia is dependent on the LCK kinase and various interacting proteins. PMID: 23872305
    5. When compared with SET-NUP214-negative patients, SET-NUP214-positive patients showed a significantly higher rate of corticosteroid resistance (91% vs 44%; P = .003) and chemotherapy resistance (100% vs 44%; P = .0001). PMID: 24449214
    6. The expression of endogenous Nup214 is significantly down-regulated by the reverse inserted lentiviral promoter PMID: 23831628
    7. Nucleoporin p62 (NUP62) and nucleoporin 214 (NUP214) are differentially distributed between nuclear pore complexes. PMID: 22558357
    8. Data describe the relatively high incidence of SET-NUP214 rearrangement in adult T-ALLs, and demonstrate comprehensive clinical, phenotypic, and genetic characteristics of this entity. PMID: 21720744
    9. Used MALDI-TOF MS 40-plex assay for testing 40 loci within 21 high-ranking breast cancer CAN-genes. No mutation could be found in 6 cell lines. A single breast cancer tissue sample showed heterozygosity at locus c.5834G>A within the ZFYVE26 gene. PMID: 21691751
    10. NUP214-ABL1 positive T-cell acute lymphoblastic leukemia patient shows an initial favorable response to imatinib therapy post relapse PMID: 21489623
    11. Cell lines LOUCY and MEGAL express the recently described SET-NUP214 fusion gene. PMID: 19166587
    12. Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus. PMID: 12191473
    13. A surface hydrophobic corridor within the MH2 domain of Smad3 is critical for association with CAN/Nup214 and nuclear import, whereas Smad4 interaction with CAN/Nup214, and nuclear import requires structural elements present only in the full-length Smad4 PMID: 12917407
    14. leukemia SET-CAN fusion protein inhibited proliferation of U937 cells, most likely by interfering with hCRM1, but it also partially blocks differentiation PMID: 14671643
    15. Nup214 has a role in regulating TTP localization PMID: 14766228
    16. NUP214-ABL1 expression defines a new subgroup of individuals with T-ALL PMID: 15361874
    17. A mechanism is proposed by which the C-terminal peptide extension is involved in nuclear pore complex assembly. PMID: 17264208
    18. TAF-Ialpha/CAN and TAF-Ibeta/CAN fusion transcripts are generated by chromosome 9q34 deletion in acute myeloid leukemia PMID: 17296573
    19. Impairment of erythroid and megakaryocytic differentiation by a leukemia-associated and t(9;9)-derived product, SET/TAF-IBeta-CAN/Nup214. PMID: 17620317
    20. Set/TAF-Ibeta acts as a ligand-activated GR-responsive transcriptional repressor, while Set-Can does not retain physiologic responsiveness to ligand-bound glucocorticoid receptor. PMID: 18096310
    21. SET-NUP214 binds in the promoter regions of specific HOXA genes, where it interacts with CRM1 and DOT1L, which may transcriptionally activate specific members of the HOXA cluster. PMID: 18299449
    22. NUP214-ABL1 fusion is unique because of its requisite localization to the nuclear pore complex for its transforming potential. PMID: 18614052
    23. a thorough biochemical comparative analysis of NUP214-ABL1 and BCR-ABL1 show that, despite their common tyrosine kinase domain, the two fusion proteins differ in many critical catalytic properties PMID: 18784740
    24. FISH revealed a heterogeneous pattern of NUP214-ABL1 amplification. NUP214-ABL1 gene requires amplification for oncogenicity; it is part of a multistep process of leukemogenesis; and it can be a late event present only in subpopulations PMID: 18923437
    25. Using in vitro assays, the authors demonstrate that NUP214 decreases both the RNA binding and ATPase activities of DBP5. PMID: 19219046
    26. CAN/Nup214 is a nuclear receptor for the herpesvirus capsid. PMID: 19386703
    27. Nup214 domain-specific localization by immunoelectron microscopy. Transport studies show that the spatial distribution of the FG-repeat domains of both Nup153 and Nup214 shifts in a transport-dependent manner. PMID: 16045929

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  • 相关疾病：
    A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene.
  • 亚细胞定位：
    Nucleus, nuclear pore complex.
  • 组织特异性：
    Expressed in thymus, spleen, bone marrow, kidney, brain and testis, but hardly in all other tissues or in whole embryos during development.
  • 数据库链接：

    HGNC: 8064

    OMIM: 114350

    KEGG: hsa:8021

    STRING: 9606.ENSP00000352400

    UniGene: Hs.654530

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