Recombinant Human Nuclear factor of activated T-cells 5 (NFAT5), partial

1. Results show that higher levels of NFAT5 expression predict a good prognosis in patients with hepatocellular carcinoma (HCC), suggesting that NFAT5 is a potential tumor-suppressing gene, and verify that NFAT5 promotes hepatoma cell apoptosis and inhibits cell growth in vitro. Also, HBV inhibits NFAT5 expression by inducing hypermethylation of the AP1-binding site in the NFAT5 promoter. PMID: 29052520
2. the NFAT5 pathway was involved in the regulation of biomechanical stretch-induced human arterial smooth muscle cell (HUASMC) proliferation, inflammation, and migration. Stretch promoted the expression of NFAT5 in human arterial smooth muscle cells and regulated through activation of c-Jun N-terminal kinase under these conditions PMID: 28840417
3. TonEBP suppresses M2 phenotype via downregulation of the IL-10 in M1 macrophages. PMID: 27160066
4. In addition to finding many proteins already known to associate with NFAT5, many new ones whose function suggest novel aspects of NFAT5 regulation, interaction, and function, were also found. PMID: 27764768
5. The data suggest that in addition to calcium signaling and activation of inflammatory enzymes, autocrine/paracrine purinergic signaling contributes to the stimulatory effect of hyperosmotic stress on the expression of the NFAT5 gene in retinal pigment epithelial cells. PMID: 28356704
6. NFAT5-mediated expression of CACNA1C is evolutionarily conserved. NFAT5-mediated CACNA1C expression is critical for cardiac electrophysiological development and maturation. PMID: 27368804
7. Data suggest that protease 2A of CVB3 exhibits substrate specificity that includes human/mouse NFAT5 in cardiomyocytes; NFAT5 inhibits CVB3 replication via mechanism that involves iNOS; anti-CVB3 activity of NFAT5 is impaired during CVB3 infection due to protease 2A-mediated cleavage of NFAT5. (CVB3 = Coxsackievirus 3; NFAT5 = tonicity-responsive nuclear factor of activated T-cells 5; iNOS = nitric oxide synthase type II) PMID: 29220410
8. TonEBP expression correlated with canonical osmoregulatory targets TauT/SLC6A6, SMIT/SLC5A3, and AR/AKR1B1, supporting in vitro findings that the inflammatory milieu during IDD does not interfere with TonEBP osmoregulation. In summary, whereas TonEBP participates in the proinflammatory response to TNF-alpha PMID: 28842479
9. results provide evidence that NFAT5 expression in macrophages enhances chronic arthritis by conferring apoptotic resistance to activated macrophages. PMID: 28192374
10. genetic variation in NFAT5 expression and function in the central nervous system may affect the regulation of systemic water balance PMID: 28360221
11. The hyperosmotic AR gene expression was dependent on activation of metalloproteinases, autocrine/paracrine TGF-beta signaling, activation of p38 MAPK, ERK1/2, and PI3K signal transduction pathways, and the transcriptional activity of NFAT5. PMID: 27628063
12. Conclusion. miR-20b acts as a tumor suppressor in the development of thymoma and thymoma-associated myasthenia gravis. The tumor suppressive function of miR-20b in thymoma could be due to its inhibition of NFAT signaling by repression of NFAT5 and CAMTA1 expression. PMID: 27833920
13. The hyperosmotic, but not the hypoxic, PlGF gene expression was in part mediated by NFAT5. PMID: 27230578
14. Proteins associated with and binding NH2-terminal region of NFAT5.NUP160 and NUP205 contribute to regulation of NFAT5 transcriptional activity PMID: 26757802
15. Our data demonstrates the involvement of TonEBP in the mechanisms responsible for osmoadaptation to hyperosmolar stress in retinal pigment epithelium cells. PMID: 26912969
16. Additionally, in peritoneal dialysis the cells of the peritoneal cavity are repeatedly exposed to a rise and fall in osmotic concentrations. Here we review the current information about NFAT5 in uremic patients and patients on peritoneal dialysis. PMID: 26495302
17. Results suggest that the NFAT5 gene, which is upregulated a few hours after cocaine exposure, may be involved in the genetic predisposition to cocaine dependence. PMID: 26506053
18. NFAT5 pathway activation might have a relevant role in inflammatory breast cancer pathogenesis PMID: 25928084
19. Real-time PCR and Western blot analysis confirmed up-regulation of NFAT5 mRNA and NFAT5 nuclear content in human preeclamptic placentas PMID: 25995271
20. These results indicate that NFAT5 plays important roles in proliferation and migration of human lung adenocarcinoma cells through regulating AQP5 expression, providing a new therapeutic option for lung adenocarcinoma therapy. PMID: 26299924
21. The hyperosmotic induction of AQP5 and VEGF in retinal pigment epithelial cells was in part dependent on activation of NFAT5. PMID: 25878490
22. Upregulation of NFAT5 in peritoneal dialysis patients is associated with NFkappaB induction, potentially resulting in the recruitment of macrophages PMID: 25834072
23. NFAT5 participates in the regulation of intestinal homeostasis via the suppression of mTORC1/Notch signaling pathway. PMID: 25057011
24. PKC-alpha contributes to high NaCl-dependent activation of NFAT5 through ERK1/2. PMID: 25391900
25. Data indicate that nuclear factor of activated T cells 5 (NFAT5) is a direct target of miR-568. PMID: 24355664
26. these data support a novel function of the XO-NFAT5 axis in macrophage activation and TLR-induced arthritis PMID: 25044064
27. Suggest that biomechanical stretch is sufficient to activate NFAT5 both in native and cultured VSMCs where it regulates the expression of tenascin-C. PMID: 24614757
28. NFAT5 regulation of intestinal cell differentiation may be through inhibition of Wnt/beta-catenin signaling. PMID: 23764852
29. Nfat5 may be involved in regulating chondrogenic differentiation of these cells under both normal and increased osmolarities and might regulate chondrogenic differentiation through influencing early Sox9 expression PMID: 23219947
30. It was concluded that specific DNA binding of NFAT5 contributes to its nuclear localization, by mechanisms as yet undetermined, but independent of ones previously described. PMID: 22992674
31. Non-invasive imaging of nuclear factor of activated T-cell 5 (NFAT5) activation follows middle cerebral artery occlusion (MCAO) in NFAT5-luciferase-expressing mice. PMID: 21749466
32. NFAT5 is induced by hypoxia and could be a protective factor against ischemic damage. PMID: 22768306
33. NFAT5 contributes to osmolality-induced MCP-1 expression in mesothelial cells PMID: 22619484
34. The nuclear transport of NFAT5a involves reversible palmitoylation. PMID: 22071693
35. the innate immune response to MTb infection induces NFAT5 gene and protein expression, and NFAT5 plays a crucial role in MTb regulation of HIV-1 replication via a direct interaction with the viral promoter. PMID: 22496647
36. These data indicate that NS5A modulates Hsp72 via NFAT5 and reactive oxygen species activation for hepatitis C virus propagation. PMID: 22497815
37. These results suggested that TonEBP played an important role in the epithelial cells of renal proximal tubule upon hypertonic stress by enhancing AAD expression, which could promote dopamine secretion to negative regulate Na+/K+-ATPase activity. PMID: 21982764
38. Compared with control group, the levels of OREBP, HSP70-2 and MUC5AC in supernatant significantly increased after HBE16 cells were exposed to hypertonic media. PMID: 21418859
39. Identify NFAT5 as a novel regulator of vascular smooth muscle cell phenotypic modulation. PMID: 21757659
40. NF-AT5 regulates synovial proliferation and angiogenesis in chronic arthritis. PMID: 21717420
41. this study demonstrates that hyperosmotic stress induces S100A4 through NFAT5, and Src and chromatin remodeling are involved. PMID: 21289293
42. High NaCl-induced increase of the overall abundance of TonEBP/OREBP, by itself, eventually raises its effective level in the nucleus, but its rapid CDK5-dependent nuclear localization accelerates the process. PMID: 21209322
43. These findings reveal a novel role for TonEBP and Akt in NF-kappaB activation on the onset of hypertonic challenge. PMID: 20685965
44. NFAT5-null mice have constitutive, pronounced hypernatremia and suffer severe immunodeficiency with T cell lymphopenia, altered CD8 naive/memory homeostasis, and inability to reject allogeneic tumors. PMID: 21037089
45. c-Abl is the kinase responsible for high NaCl-induced phosphorylation of TonEBP/OREBP-Y143 PMID: 20585028
46. TonEBP/OREBP is extensively regulated by phosphatases, including SHP-1, whose inhibition by high NaCl increases phosphorylation of TonEBP/OREBP at Y143, contributing to the nuclear localization and activation of TonEBP/OREBP PMID: 20351292
47. The loss of nucleosome(s) was found to be initiated by an OREBP-independent mechanism, but was significantly potentiated in the presence of OREBP. PMID: 20041176
48. TonEBP/OREBP becomes phosphorylated at Y143, resulting in binding of PLC-gamma1 to that site, which contributes to TonEBP/OREBP transcriptional activity. PMID: 20080774
49. NFAT5 exclusion from mitotic chromatin resets its nucleo-cytoplasmic distribution in interphase PMID: 19750013
50. present in placenta at RNA and protein levels PMID: 19886771

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HGNC: 7774

OMIM: 604708

KEGG: hsa:10725

STRING: 9606.ENSP00000396538

UniGene: Hs.371987