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  4. Recombinant Human Neuronal PAS domain-containing protein 3 (NPAS3), partial

Recombinant Human Neuronal PAS domain-containing protein 3 (NPAS3), partial

  • 中文名称：
    人NPAS3重组蛋白
  • 货号：
    CSB-YP814222HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人NPAS3重组蛋白
  • 货号：
    CSB-EP814222HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人NPAS3重组蛋白
  • 货号：
    CSB-EP814222HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人NPAS3重组蛋白
  • 货号：
    CSB-BP814222HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人NPAS3重组蛋白
  • 货号：
    CSB-MP814222HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    NPAS3
  • Uniprot No.：
    Q8IXF0
  • 别名：
    Basic helix loop helix PAS protein MOP6 ; Basic-helix-loop-helix-PAS protein MOP6; bHLHe12; Class E basic helix-loop-helix protein 12; FLJ10003; FLJ11138; FLJ11605; Member of PAS protein 6; MOP 6; MOP6; Neuronal PAS domain containing protein 3; Neuronal PAS domain protein 3; Neuronal PAS domain-containing protein 3; Neuronal PAS3; NPAS 3; NPAS3; NPAS3_HUMAN; PAS domain-containing protein 6; PASD 6; PASD6
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a broad role in neurogenesis. May control regulatory pathways relevant to schizophrenia and to psychotic illness.
  • 基因功能参考文献：
    1. Study provides a clear, unbiased view of the full spectrum of genes regulated by NPAS1 and NPAS3 and shows that these transcription factors are master regulators of neuropsychiatric function. These findings expose the molecular pathophysiology of NPAS1/3 mutations and provide a striking example of the shared, combinatorial nature of molecular pathways that underlie diagnostically distinct neuropsychiatric conditions. PMID: 28499489
    2. Here the authors examined the crystal structures of multi-domain NPAS1-ARNT and NPAS3-ARNT-DNA complexes, discovering each to contain four putative ligand-binding pockets. PMID: 27782878
    3. Authors hypothesize that any nucleotide variant at the NPAS3 HAEs may lead to altered susceptibility to schizophrenia. PMID: 25982957
    4. Identification of NPAS3-V304I helps strengthen the hypothesis that NPAS3 is involved in schizophrenia pathogenesis PMID: 23337948
    5. The accelerated non-coding region 2xHAR142 of NPAS3 behaves as a developmental enhancer in the forebrain of transgenic mice. PMID: 24218632
    6. Results indicate that the high density of HAEs present in the human NPAS3 locus could have modified the spatiotemporal expression pattern of NPAS3 in the developing human brain and, therefore, contributed to human brain evolution. PMID: 23408798
    7. During human postnatal cortical development, there was decreased NPAS3 mRNA yet increased NPAS3 protein expression, suggesting the involvement of posttranscriptional regulation, which results show is modified by miR-17. PMID: 22228753
    8. In a HEK293 cell line over-expressing NPAS3, transcriptional targets varied with to circadian rhythm context & C-terminal deletion. NPAS3 contributes to neurodevelopmental transcription factor networks & the regulation of brain glucose metabolism. PMID: 21709683
    9. Loss of NPAS3 is associated with the progression of Astrocytomas. PMID: 21703424
    10. report of immunohistochemical findings on NPAS3 protein expression in the developing human fetal brain during the three trimesters (10-41 weeks) of gestational development PMID: 21306425
    11. This study identification of potentially defective NPAS3 variants supports recent studies that implicate perturbations in NPAS3 pathways in impaired neurogenesis and psychosis. PMID: 20466522
    12. haploinsufficiency of NPAS3 contributes to the cause of schizophrenia PMID: 12746393
    13. This study demonstrated that these risk and protective effects act combinatorially, potentially multiplicatively, to determine NPAS3 gene-wide susceptibility in bipolar disorder and schizophrenia. PMID: 18317462
    14. Genome-wide association study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 18195134
    15. Clinical trial of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 19573479

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  • 相关疾病：
    A chromosomal aberration involving NPAS3 is found in a family with schizophrenia. Translocation t(9;14)(q34;q13).
  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Ubiquitously expressed in the adult brain.
  • 数据库链接：

    HGNC: 19311

    OMIM: 609430

    KEGG: hsa:64067

    STRING: 9606.ENSP00000348460

    UniGene: Hs.657892

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