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  4. Recombinant Human NACHT, LRR and PYD domains-containing protein 5 (NLRP5), partial

Recombinant Human NACHT, LRR and PYD domains-containing protein 5 (NLRP5), partial

  • 中文名称：
    人NLRP5重组蛋白
  • 货号：
    CSB-YP015873HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人NLRP5重组蛋白
  • 货号：
    CSB-EP015873HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人NLRP5重组蛋白
  • 货号：
    CSB-EP015873HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人NLRP5重组蛋白
  • 货号：
    CSB-BP015873HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人NLRP5重组蛋白
  • 货号：
    CSB-MP015873HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    NLRP5
  • Uniprot No.：
    P59047
  • 别名：
    CLR19.8; MATER; Mater protein homolog; Maternal antigen that embryos require; NACHT, leucine rich repeat and PYD containing 5; NACHT, LRR and PYD domains-containing protein 5; NALP5_HUMAN; NLR family, pyrin domain containing 5; NLRP5; Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 5; PAN11; PYPAF8
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics. Required for the formation of F-actin cytoplasmic lattices (CPL) in oocytes, which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning. Required for the localization of cortical granules to the cortex of oocytes, via association with the cortical actin scaffold. Required for cortical actin clearance prior to oocyte exocytosis. Involved in regulating post-fertilization Ca(2+) release and endoplasmic reticulum (ER) storage via regulation of ER localization. May be involved in the localization of mitochondria to the cytoplasm and perinuclear region in oocytes and early stage embryos, independent of its role in CPL formation.
  • 基因功能参考文献：
    1. PSMG4 and NLRP5 appear of particular interest as they were found to be associated with more than one clinical phenotype and are implicated in biological processes considered relevant to the pathophysiology of MS. Also, PSMG4 p.W99R and NLRP5 p.R761L were found to correlate with an earlier age of MS clinical onset. Our data suggests PSMG4 and NLPR5 as potential targets for the development of modifying therapies for MS. PMID: 28501589
    2. expression of MATER and NOX4 proteins are closely related to the follicular development and ovulation with particular regard for ovarian aging PMID: 27515505
    3. NLRP5 mutation is associated with multilocus imprinting disorders and reproductive wastage. PMID: 26323243
    4. characterization of the MATER gene and its protein; this provides a basis for investigating their clinical implications in autoimmune premature ovarian failure and infertility in women PMID: 11925379
    5. NALP5 appears to be a tissue-specific autoantigen involved in hypoparathyroidism in patients with APS-1. Autoantibodies against NALP5 appear to be highly specific and may be diagnostic for this prominent component of APS-1 PMID: 18322283
    6. The nuclear, nucleolar and mitochondrial localization hints at a possible role in RNA processing and the metabolic activity of the cell. PMID: 19192343
    7. MATER protein interacts with tPKCepsilon in cumulus cells under physiological conditions. PMID: 19542546

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  • 亚细胞定位：
    Cytoplasmic vesicle, secretory vesicle, Cortical granule. Mitochondrion. Nucleus, nucleolus. Cytoplasm. Golgi apparatus.
  • 蛋白家族：
    NLRP family
  • 组织特异性：
    Expressed in cumulus cells (at protein level). Highly abundant in oocytes and early embryos, however poorly expressed in somatic tissues such as the liver and spinal cord.
  • 数据库链接：

    HGNC: 21269

    OMIM: 609658

    KEGG: hsa:126206

    STRING: 9606.ENSP00000375063

    UniGene: Hs.356872

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