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  4. Recombinant Human Methyltransferase-like protein 21B (METTL21B)

Recombinant Human Methyltransferase-like protein 21B (METTL21B)

  • 中文名称：
    人EEF1AKMT3重组蛋白
  • 货号：
    CSB-YP836184HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人EEF1AKMT3重组蛋白
  • 货号：
    CSB-EP836184HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人EEF1AKMT3重组蛋白
  • 货号：
    CSB-EP836184HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人EEF1AKMT3重组蛋白
  • 货号：
    CSB-BP836184HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人EEF1AKMT3重组蛋白
  • 货号：
    CSB-MP836184HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    EEF1AKMT3
  • Uniprot No.：
    Q96AZ1
  • 别名：
    FAM119B; Hepatocellular carcinoma-associated antigen 557a; Methyltransferase like 21B; Methyltransferase-like protein 21B; mettl21b; MT21B_HUMAN; Protein-lysine methyltransferase METTL21B
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-226
  • 氨基酸序列
    MADPGPDPES ESESVFPREV GLFADSYSEK SQFCFCGHVL TITQNFGSRL GVAARVWDAA LSLCNYFESQ NVDFRGKKVI ELGAGTGIVG ILAALQGGDV TITDLPLALE QIQGNVQANV PAGGQAQVRA LSWGIDHHVF PANYDLVLGA DIVYLEPTFP LLLGTLQHLC RPHGTIYLAS KMRKEHGTES FFQHLLPQHF QLELAQRDED ENVNIYRARH REPRPA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Protein-lysine methyltransferase that selectively mono-, di- and trimethylates 'Lys-165' of the translation elongation factors EEF1A1 and EEF1A2 in an aminoacyl-tRNA and GTP-dependent manner. EEF1A1 methylation by EEF1AKMT3 is dynamic as well as inducible by stress conditions, such as ER-stress, and plays a regulatory role on mRNA translation.
  • 基因功能参考文献：
    1. Results have shown that METTL21B is a protein methyltransferase that methylates both isoforms of translation elongation factor eEF1A at lysine 165. Also, further data suggests that METTL21B has an evolutionarily important role for the methylation of lysine 165 in eEF1A. PMID: 28663172
    2. The present study identifies METTL21B as the enzyme responsible for methylation of eEF1A on Lys-165 and shows that this modification is dynamic, inducible and likely of regulatory importance. PMID: 28108655
    3. The METTL21B protein is here suggested to be a protein methyltransferase, as it is shown to belong to a family of 10 human methyltransferases, some of which are shown to have lysine specific protein methyltransferase activity. PMID: 22948820
  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族：
    Methyltransferase superfamily, METTL21 family
  • 数据库链接：

    HGNC: 24936

    OMIM: 615258

    KEGG: hsa:25895

    UniGene: Hs.632720

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