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  4. Recombinant Human Mediator of RNA polymerase II transcription subunit 13 (MED13), partial

Recombinant Human Mediator of RNA polymerase II transcription subunit 13 (MED13), partial

  • 中文名称：
    人MED13重组蛋白
  • 货号：
    CSB-YP883407HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人MED13重组蛋白
  • 货号：
    CSB-EP883407HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人MED13重组蛋白
  • 货号：
    CSB-EP883407HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人MED13重组蛋白
  • 货号：
    CSB-BP883407HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人MED13重组蛋白
  • 货号：
    CSB-MP883407HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    MED13
  • Uniprot No.：
    Q9UHV7
  • 别名：
    MED13; ARC250; KIAA0593; THRAP1; TRAP240; Mediator of RNA polymerase II transcription subunit 13; Activator-recruited cofactor 250 kDa component; ARC250; Mediator complex subunit 13; Thyroid hormone receptor-associated protein 1; Thyroid hormone receptor-associated protein complex 240 kDa component; Trap240; Vitamin D3 receptor-interacting protein complex component DRIP250; DRIP250
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

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MED13 antibodies

靶点详情

  • 功能：
    Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
  • 基因功能参考文献：
    1. Each of HSPA4 and MED13 mutations were detected in GC. PMID: 27129500
    2. Cardiac overexpression of MED13 in transgenic mice confers a lean phenotype that is associated with increased lipid uptake, beta-oxidation and mitochondrial content in white adipose tissue and liver PMID: 25422356
    3. Med12 and Med13 are critical for human CDK8 subcomplex -dependent repression, whereas CDK8 kinase activity is not PMID: 19240132
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Mediator complex subunit 13 family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 22474

    OMIM: 603808

    KEGG: hsa:9969

    STRING: 9606.ENSP00000380888

    UniGene: Hs.282678

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