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  4. Recombinant Human Mdm2-binding protein (MTBP), partial

Recombinant Human Mdm2-binding protein (MTBP), partial

  • 中文名称：
    人MTBP重组蛋白
  • 货号：
    CSB-YP856921HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人MTBP重组蛋白
  • 货号：
    CSB-EP856921HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人MTBP重组蛋白
  • 货号：
    CSB-EP856921HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人MTBP重组蛋白
  • 货号：
    CSB-BP856921HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人MTBP重组蛋白
  • 货号：
    CSB-MP856921HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    MTBP
  • Uniprot No.：
    Q96DY7
  • 别名：
    hMTBP; MDM 2 binding protein; MDM 2 BP; MDM2 (mouse double minute 2) binding protein 104kD; MDM2 (mouse double minute 2) binding protein; MDM2 binding protein; MDM2 BP; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein 104kDa; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein binding protein; Mdm2-binding protein; MDM2BP; Mouse double minute 2 homolog binding protein; MTBP; MTBP_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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MTBP antibodies

靶点详情

  • 功能：
    Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells. May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation.
  • 基因功能参考文献：
    1. data show that MTBP aggravates the invasion and metastasis of HCC by promoting the MDM2-mediated degradation of E-cadherin. PMID: 26280083
    2. Overexpression of MTBP resulted in the suppression of the migratory and metastatic potential of Hepatocellular carcinoma cells, while its downregulation increased the migration. PMID: 25759210
    3. MTBP significantly contributes to breast cancer survival and is a potential novel therapeutic target in Triple-negative breast cancer . PMID: 24866769
    4. MTBP associated with MYC at promoters and increased MYC-mediated transcription, proliferation, neoplastic transformation, and tumor development. PMID: 24786788
    5. MTBP acts with Treslin/TICRR to integrate signals from cell cycle and DNA damage response pathways to control the initiation of DNA replication in human cells. PMID: 23704573
    6. MTBP also inhibited ACTN4-mediated F-actin bundling. PMID: 22370640
    7. identification and characterization of mouse Mdm2 binding protein PMID: 10906133
    8. MTBP has an important role in recruiting and/or retaining the Mad1/Mad2 complex at the kinetochores during prometaphase, but its degradation is required for silencing the mitotic checkpoint. PMID: 21274008
    9. results represent the first examination of MTBP expression in human tissues and provide evidence for a p53 status-dependent role for MTBP in suppressing disease progression in squamous cell carcinoma of the head and neck patients PMID: 21692053
    10. Data suggest that MTBP differentially regulates the activity of MDM2 towards two of its most critical targets (itself and p53) and in doing so significantly contributes to MDM2-dependent p53 homeostasis in unstressed cells. PMID: 15632057
    11. MTBP contributes to MDM2 activity and through this to negative regulation of p53 PMID: 15632057

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  • 蛋白家族：
    MTBP family
  • 数据库链接：

    HGNC: 7417

    OMIM: 605927

    KEGG: hsa:27085

    STRING: 9606.ENSP00000303398

    UniGene: Hs.657656

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