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  4. Recombinant Human Mastermind-like protein 3 (MAML3), partial

Recombinant Human Mastermind-like protein 3 (MAML3), partial

  • 中文名称：
    人MAML3重组蛋白
  • 货号：
    CSB-YP839351HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人MAML3重组蛋白
  • 货号：
    CSB-EP839351HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人MAML3重组蛋白
  • 货号：
    CSB-EP839351HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人MAML3重组蛋白
  • 货号：
    CSB-BP839351HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人MAML3重组蛋白
  • 货号：
    CSB-MP839351HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    MAML3
  • Uniprot No.：
    Q96JK9
  • 别名：
    AV234550; BC049812; CAG repeat containing (glia-derived nexin I alpha); CAG repeat domain; CAGH3; ERDA3; Expanded repeat domain, CAG/CTG 3; GDN; KIAA1816; MAM 2; Mam 3; MAM2; MAML3; MAML3_HUMAN; mastermind like 3 (Drosophila); Mastermind like 3; Mastermind like transcriptional coactivator 3; Mastermind-like protein 3; MGC59565; mKIAA1816; Polyglutamine rich; TNRC3; Trinucleotide repeat containing 3
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1.
  • 基因功能参考文献：
    1. RBPJ and MAML3 could be new therapeutic targets for SCLC. PMID: 30061220
    2. PTTG1IP and MAML3 are associated with BHR severity in adult asthma. The relevance of these genes is supported by the eQTL analyses and co-expression of PTTG1lP with vimentin and E-cadherin1, and MAML3 with MAML2. PMID: 27709636
    3. These findings indicate that the miR-2392-MAML3/WHSC1-Slug/Twist1 regulatory axis plays a critical role in GC metastasis. PMID: 28512191
    4. Results show that overexpression of MAML3 confers resistance to retinoic acid in multiple neuroblastoma cell lines. PMID: 26785999
    5. These results suggest that PSK suppresses Hedgehog signaling through down-regulation of MAML3 and RBPJ transcription under hypoxia, inhibiting the induction of a malignant phenotype in pancreatic cancer. Our results may lead to development of new treatments for refractory pancreatic cancer using PSK as a Hedgehog inhibitor PMID: 27466498
    6. Suggest that hypoxia promotes SMO transcription through upregulation of MAML3 and RBPJ to induce proliferation, invasiveness and tumorigenesis in pancreatic cancer. PMID: 26655998
    7. Identification of new human proteins defines a family that consists of positive regulators for notch signaling PMID: 12386158

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  • 亚细胞定位：
    Nucleus speckle. Note=Nuclear, in a punctate manner.
  • 蛋白家族：
    Mastermind family
  • 数据库链接：

    HGNC: 16272

    OMIM: 608991

    KEGG: hsa:55534

    STRING: 9606.ENSP00000421180

    UniGene: Hs.586165

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