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  4. Recombinant Human Malate dehydrogenase, mitochondrial (MDH2)

Recombinant Human Malate dehydrogenase, mitochondrial (MDH2)

  • 中文名称：
    人MDH2重组蛋白
  • 货号：
    CSB-YP013623HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人MDH2重组蛋白
  • 货号：
    CSB-EP013623HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人MDH2重组蛋白
  • 货号：
    CSB-BP013623HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人MDH2重组蛋白
  • 货号：
    CSB-MP013623HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    MDH2
  • Uniprot No.：
    P40926
  • 别名：
    M MDH; Malate dehydrogenase 2; NAD (mitochondrial); Malate dehydrogenase; Malate dehydrogenase; mitochondrial; MDH; mdh2; MDHM_HUMAN; MGC:3559; mitochondrial; Mitochondrial malate dehydrogenase 2; NAD; Mor 1; MOR1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    25-338
  • 氨基酸序列
    AKVAVL GASGGIGQPL SLLLKNSPLV SRLTLYDIAH TPGVAADLSH IETKAAVKGY LGPEQLPDCL KGCDVVVIPA GVPRKPGMTR DDLFNTNATI VATLTAACAQ HCPEAMICVI ANPVNSTIPI TAEVFKKHGV YNPNKIFGVT TLDIVRANTF VAELKGLDPA RVNVPVIGGH AGKTIIPLIS QCTPKVDFPQ DQLTALTGRI QEAGTEVVKA KAGAGSATLS MAYAGARFVF SLVDAMNGKE GVVECSFVKS QETECTYFST PLLLGKKGIE KNLGIGKVSS FEEKMISDAI PELKASIKKG EDFVKTLK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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MDH2 Proteins

靶点详情

  • 基因功能参考文献：
    1. these data suggest that MDH2, functioning as an RNA-binding protein, is involved in the posttranscriptional downregulation of SCN1A expression under seizure condition. PMID: 28433711
    2. loss-of-function mutations in MDH2 are also associated with severe neurological clinical presentations in children PMID: 27989324
    3. Data indicate that acetyl-CoA acetyltransferase (ACAT1) and malate dehydrogenase (MDH2) are involved in various drug-resistance-forming mechanisms. PMID: 25639359
    4. Segregation of the mutation with disease and absence of MDH2 in mutated tumors revealed MDH2 as a novel pheochromocytoma/paraganglioma susceptibility gene. PMID: 25766404
    5. L-2-hydroxyglutarate accumulates as a result of a deficiency in FAD-linked L-2-hydroxyglutarate dehydrogenase. mitochondrial L-malate dehydrogenase is responsible for the excretion of L-2-hydroxyglutarate in this condition. PMID: 17603759

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  • 相关疾病：
    Epileptic encephalopathy, early infantile, 51 (EIEE51)
  • 亚细胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    LDH/MDH superfamily, MDH type 1 family
  • 数据库链接：

    HGNC: 6971

    OMIM: 154100

    KEGG: hsa:4191

    STRING: 9606.ENSP00000327070

    UniGene: Hs.520967

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