Recombinant Human MORC family CW-type zinc finger protein 4 (MORC4), partial

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中文名称：

人MORC4重组蛋白
货号：

CSB-EP840578HU
规格：

￥2328
图片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

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纯度：

Greater than 90% as determined by SDS-PAGE.
基因名：

MORC4
Uniprot No.：

Q8TE76
别名：

(Zinc finger CW-type coiled-coil domain protein 2)(Zinc finger CW-type domain protein 4)
种属：

Homo sapiens (Human)
蛋白长度：

Partial
来源：

E.coli
分子量：

57.2 kDa
表达区域：

29-486aa
氨基酸序列

GIRLSTMSPRYLQSNSSSHTRPFSAIAELLDNAVDPDVSARTVFIDVEEVKNKSCLTFTDDGCGMTPHKLHRMLSFGFTDKVIKKSQCPIGVFGNGFKSGSMRLGKDALVFTKNGGTLTVGLLSQTYLECVQAQAVIVPIVPFNQQNKKMIITEDSLPSLEAILNYSIFNRENDLLAQFDAIPGKKGTRVLIWNIRRNKNGKSELDFDTDQYDILVSDFDTEEKMTGGVTSELPETEYSLRAFCGILYMKPRMKIFLRQKKVTTQMIAKSLANVEYDTYKPTFTNKQVRITFGFSCKNSNQFGIMMYHNNRLIKSFEKVGCQVKPTRGEGVGVIGVIECNFLKPAYNKQDFEYTKEYRLTINALAQKLNAYWKEKTSQDNFETSTVARPIPKVPDQTWVQCDECLKWRKLPGKIDPSMLPARWFCYYNSHPKYRRCSVPEEQELTDEDLCLSKAKKQE
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
蛋白标签：

N-terminal 10xHis-tagged and C-terminal Myc-tagged
产品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
缓冲液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
复溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
储存条件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保质期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
货期：

3-7 business days
注意事项：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

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功能：

Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3. The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0.
基因功能参考文献：
1. SNP in the MORC4-rs 12837024 is associated with Chronic pancreatitis. PMID: 28913878
2. Genetic variation in MORC4, CD14, and TLR4 may affect the outcome of allogeneic stem cell transplantation. PMID: 26827181
3. Genetic variants in CLDN2 and MORC4 genes were associated with chronic pancreatitis in Indian patients. PMID: 26820620
4. Single nucleotide polymorphism is a risk factor developing chronic alcoholic pancreatitis. PMID: 25253127
5. Findings suggest that a variant of the CLDN2-MORC4 region predisposes to Crohn's disease in a Swedish population. PMID: 23946598
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亚细胞定位：

Nucleus.
组织特异性：

Expressed at low levels in normal tissues, with highest expression levels in placenta and testis. Expression is significantly increased in subset of diffuse large B-cell lymphomas.
数据库链接：

HGNC: 23485

OMIM: 300970

KEGG: hsa:79710

STRING: 9606.ENSP00000347821

UniGene: Hs.496544

Recombinant Human MORC family CW-type zinc finger protein 4 (MORC4), partial

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