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  4. Recombinant Human MAM domain-containing glycosylphosphatidylinositol anchor protein 1 (MDGA1), partial

Recombinant Human MAM domain-containing glycosylphosphatidylinositol anchor protein 1 (MDGA1), partial

  • 中文名称：
    人MDGA1重组蛋白
  • 货号：
    CSB-YP850880HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人MDGA1重组蛋白
  • 货号：
    CSB-EP850880HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人MDGA1重组蛋白
  • 货号：
    CSB-EP850880HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人MDGA1重组蛋白
  • 货号：
    CSB-BP850880HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人MDGA1重组蛋白
  • 货号：
    CSB-MP850880HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    MDGA1
  • Uniprot No.：
    Q8NFP4
  • 别名：
    Glycosyl phosphatidyl inositol MAM; Glycosylphosphatidylinositol-MAM; GPI and MAM protein; GPIM; MAM domain-containing glycosylphosphatidylinositol anchor protein 1; MAM domain-containing protein 3; MAMDC3; Mdga1; MDGA1_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required for radial migration of cortical neurons in the superficial layer of the neocortex. Plays a role in the formation or maintenance of inhibitory synapses. May function by inhibiting the activity of NLGN2.
  • 基因功能参考文献：
    1. MDGAs regulate the formation of neuroligin-neurexin trans-synaptic bridges by sterically blocking access of neurexins to neuroligins. PMID: 28641112
    2. The MDGA1 gene may confer risk to schizophrenia and bipolar disorder in Chinese Han population. PMID: 21146959
    3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    4. A novel human gene mapped to chromosome 6p21, encodes a putative glycosylphosphatidylinositol (GPI) anchored protein containing a MAM (meprin, A5 antigen, protein tyrosine phosphatase mu) domain. (GPIM) PMID: 12082541
    5. MDGA1, a novel glycosylphosphatidylinositol-anchored protein, is localized in lipid rafts. PMID: 15922729
    6. MDGA1 is a new schizophrenia susceptibility gene, and altered neuronal migration is involved in SZ pathology. PMID: 18384059
    7. Observational study of gene-disease association. (HuGE Navigator) PMID: 20036297
    8. Observational study of gene-disease association. (HuGE Navigator) PMID: 18384059

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor. Note=Associated with lipid rafts.
  • 组织特异性：
    Has been found in brain, heart, skeletal muscle and kidney. Found to be overexpressed in tumor tissues.
  • 数据库链接：

    HGNC: 19267

    OMIM: 609626

    KEGG: hsa:266727

    STRING: 9606.ENSP00000402584

    UniGene: Hs.437993

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