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  4. Recombinant Human Lysine-specific demethylase PHF2 (PHF2), partial

Recombinant Human Lysine-specific demethylase PHF2 (PHF2), partial

  • 中文名称：
    人PHF2重组蛋白
  • 货号：
    CSB-YP017908HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PHF2重组蛋白
  • 货号：
    CSB-EP017908HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PHF2重组蛋白
  • 货号：
    CSB-EP017908HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PHF2重组蛋白
  • 货号：
    CSB-BP017908HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PHF2重组蛋白
  • 货号：
    CSB-MP017908HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PHF2
  • Uniprot No.：
    O75151
  • 别名：
    CENP-35; GRC5; JHDM1E; Jumonji C domain containing histone demethylase 1E ; Lysine-specific demethylase PHF2; PHD finger protein 2; Phf2; PHF2_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA. Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters.
  • 基因功能参考文献：
    1. Our results demonstrate that the IKAROS promotes PHF2 expression, and suggest that PHF2 (low) expression works with the IKAROS gene deletion to drive oncogenesis of ALL PMID: 28994305
    2. Frameshift mutations of PHF2 may play a role in tumorigenesis through its TSG inactivation in CRC and GC. PMID: 27744626
    3. PHF2 acts as a tumor suppressor in association with p53 in cancer development and ensures p53-mediated cell death in response to chemotherapy. PMID: 25043306
    4. PHF2 is likely to repress rDNA transcription by competing with PHF8 for binding of ribosomal DNA promoter and by recruiting H3K9me2/3 methyltransferase SUV39H1. PMID: 25204660
    5. JARID1B and PHF2 are overexpressed in esophageal squamous cell carcinoma (ESCC) and they may play crucial roles in the course of ESCC initiation and/or progression PMID: 22534467
    6. the crystal structures of PHF2 Jumonji domain in the absence and presence of additional exogenous metal ions were determined. PMID: 21167174
    7. Differential association of alterations in FANCC and PTCH1 with that of PHF2, XPA and two breast cancer susceptibility genes (BRCA1/BRCA2) in the two age groups suggests differences in their molecular pathogenesis. PMID: 18990233

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  • 亚细胞定位：
    Nucleus, nucleolus. Chromosome, centromere, kinetochore.
  • 蛋白家族：
    JHDM1 histone demethylase family, JHDM1D subfamily
  • 组织特异性：
    Widely expressed, including in liver (at protein level).
  • 数据库链接：

    HGNC: 8920

    OMIM: 604351

    KEGG: hsa:5253

    STRING: 9606.ENSP00000352185

    UniGene: Hs.211441

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