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  4. Recombinant Human Lysine-specific demethylase 7 (JHDM1D), partial

Recombinant Human Lysine-specific demethylase 7 (JHDM1D), partial

  • 中文名称：
    人KDM7A重组蛋白
  • 货号：
    CSB-YP747775HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人KDM7A重组蛋白
  • 货号：
    CSB-EP747775HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人KDM7A重组蛋白
  • 货号：
    CSB-EP747775HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人KDM7A重组蛋白
  • 货号：
    CSB-BP747775HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人KDM7A重组蛋白
  • 货号：
    CSB-MP747775HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    KDM7A
  • Uniprot No.：
    Q6ZMT4
  • 别名：
    JHDM1D; jmjc containing protein; JmjC domain-containing histone demethylation protein 1D; jumonji containing protein; KDM7_HUMAN; kiaa1718; Lysine-specific demethylase 7
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9', 'Lys-27' and 'Lys-36' (H3K9me2, H3K27me2, H3K36me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate.
  • 基因功能参考文献：
    1. KDM7A mediates TNF-alpha-induced ICAM1 protein upregulation. PMID: 27565733
    2. G9a promotes H3K27 methylation of the E-cadherin promoter by upregulating PCL3 to increase PRC2 promoter recruitment and by downregulating the H3K27 demethylase KDM7A to silence E-cadherin gene PMID: 26688070
    3. Histone modifier genes (JMJD1C, RREB1, MINA, KDM7A) alter conotruncal heart phenotypes in 22q11.2 deletion syndrome. PMID: 26608785
    4. increased JHDM1D expression suppresses tumor growth by down-regulating angiogenesis under nutrient starvation PMID: 22143793
    5. KIAA1718 is a dual-specificity histone demethylase that regulates neural differentiation through FGF4. PMID: 20084082

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    JHDM1 histone demethylase family, JHDM1D subfamily
  • 数据库链接：

    HGNC: 22224

    KEGG: hsa:80853

    STRING: 9606.ENSP00000380692

    UniGene: Hs.308710

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