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  4. Recombinant Human Lysine-specific demethylase 2A (KDM2A), partial

Recombinant Human Lysine-specific demethylase 2A (KDM2A), partial

  • 中文名称：
    人KDM2A重组蛋白
  • 货号：
    CSB-YP896494HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人KDM2A重组蛋白
  • 货号：
    CSB-EP896494HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人KDM2A重组蛋白
  • 货号：
    CSB-EP896494HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人KDM2A重组蛋白
  • 货号：
    CSB-BP896494HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人KDM2A重组蛋白
  • 货号：
    CSB-MP896494HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    KDM2A
  • Uniprot No.：
    Q9Y2K7
  • 别名：
    [Histone-H3]-lysine-36 demethylase 1A; CXXC-type zinc finger protein 8; CXXC8; F box / LRR repeat protein 11; F box and leucine rich repeat protein 11; F box protein FBL7; F-box and leucine-rich repeat protein 11; F-box protein FBL7; F-box protein Lilina; F-box/LRR-repeat protein 11; FBL11; FBL7; FBXL11; JHDM1A; JmjC domain-containing histone demethylation protein 1A; Jumonji C domain containing histone demethylase 1A ; kdm2a; KDM2A_HUMAN; LILINA; Lysine (K) specific demethylase 2A; Lysine-specific demethylase 2A
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-ARNTL/BMAL1 heterodimer and RORA in a catalytically-independent manner.
  • 基因功能参考文献：
    1. KDM2A-SF forms distinct nuclear heterochromatic bodies in an HP1a dependent manner PMID: 28816576
    2. Authors conclude that KDM2A functions as an oncogene in breast cancer by upregulating JAG1 to promote stemness, chemoresistance and angiogenesis. PMID: 27029061
    3. Identify a nucleosome interaction module within KDM2A consisting of a CXXC type zinc finger, a PHD domain and a newly identified Heterochromatin Protein 1 (HP1) interaction motif that mediates direct binding between KDM2A and HP1. This nucleosome interaction module enables KDM2A to decode nucleosomal H3K9me3 modification in addition to CpG methylation signals. PMID: 28180290
    4. The miR-29b/KDM2A axis was involved in the RUNX3-mediated inhibition of gastric cancer cell proliferation and metastasis. PMID: 27497248
    5. KDM2A-WWTR1 fusion is associated with ossifying fibromyxoid tumors. PMID: 27537276
    6. Silencing KDM2A, a histone demethylase and BCL6 co-repressor, de-repressed SFRP2 transcription by increasing histone H3K4 and H3K36 methylation at the SFRP2 promoter. PMID: 27074224
    7. Findings suggest that amplification and overexpression of the KDM2A short isoform is critical in breast cancer progression. PMID: 26207617
    8. In this study, KDM2A was identified as a novel substrate of ATM. DSB enhanced the interaction between ATM and KDM2A, which induced ATM-mediated phosphorylation of KDM2A at T632. PMID: 25823024
    9. The results suggest that under mild glucose starvation AMP-activated kinase induces KDM2A-dependent reduction of rRNA transcription to control cell proliferation. PMID: 26416883
    10. FBXL11 is proposed as a novel component of the circadian clock that regulates the circadian gene expression by a so far unknown mechanism. PMID: 26037310
    11. The protein lysine demethylases Kdm2a and Kdm2b regulate the turnover of non-phosphorylated beta-catenin specifically within the nucleus via direct interaction with the fourth and fifth armadillo repeats. PMID: 26004508
    12. Upregulation of KDM2A is very important in the progression of gastric cancer. PMID: 25245333
    13. a regulatory role for KDM2A in breast cancer cell invasion and migration, through the regulation of E2F1 function PMID: 25029110
    14. KDM2A binds to the rDNA promoter with unmethylated CpG sequences via the CxxC-ZF domain PMID: 24553073
    15. KDM2A represses histone deacetylase 3 and has a role in tumorigenicity of lung cancer cells PMID: 24482232
    16. KDMA2 is frequently overexpressed in NSCLC tumors & cell lines. It is needed for in vitro proliferation & invasion. KDM2A activated ERK1/2 by epigenetic repression of DUSP3 expression via demethylation of dimethylated H3K36 at the DUSP3 locus. PMID: 24200691
    17. KDM2A is a H3K4 demethylase that regulates cell proliferation through p15(INK4B) and p27(Kip1) in stem cells from apical papilla. PMID: 23559091
    18. FBXL11 inhibited osteo/dentinogenic differentiation potential in MSC cells by associating with BCOR, then increasing histone K4/36 methylation in Epiregulin promoter to repress Epiregulin transcription. PMID: 23074094
    19. results not only show that differently spliced transcripts from a gene result in totally opposite outcomes, but also present critical evidence of the complicated activities of KDM2A, which contains all of the five domains PMID: 22635273
    20. The oncometabolite 2-hydroxyglutarate is a competitive inhibitor of multiple alpha-ketoglutarate-dependent dioxygenases, including histone demethylases, prolyl hydroxylases, and the TET family of 5-methlycytosine hydroxylases. PMID: 21251613
    21. KDM2A represses the transcription of ribosomal RNA. KDM2A was localized in nucleoli and bound to the ribosomal RNA gene promoter. PMID: 20379134
    22. CpG islands recruit KDM2A protein, a histone H3 lysine 36 demethylase. PMID: 20417597
    23. Data describe a NF-kappaB regulatory pathway that is driven by reversible lysine methylation of p65, carried out by nuclear receptor-binding SET domain-containing protein 1 (NSD1) and F-box and leucine-rich repeat protein 11 (FBXL11). PMID: 20080798
    24. KDM2A is required to sustain centromeric integrity and genomic stability, particularly during mitosis. PMID: 19001877
    25. Data show that high levels of FBXL11 block the ability of NFkappaB to bind to DNA or activate gene expression. PMID: 19805303

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  • 亚细胞定位：
    Nucleus, nucleoplasm. Note=Punctate expression throughout the nucleoplasm and enriched in the perinucleolar region. Specifically nucleates at CpG islands where it's presence results in chromatin depleted in H3K36me2.
  • 蛋白家族：
    JHDM1 histone demethylase family
  • 组织特异性：
    Widely expressed, with highest levels in brain, testis and ovary, followed by lung.
  • 数据库链接：

    HGNC: 13606

    OMIM: 605657

    KEGG: hsa:22992

    STRING: 9606.ENSP00000432786

    UniGene: Hs.124147

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