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  4. Recombinant Human Low-density lipoprotein receptor-related protein 1B (LRP1B), partial

Recombinant Human Low-density lipoprotein receptor-related protein 1B (LRP1B), partial

  • 中文名称：
    人LRP1B重组蛋白
  • 货号：
    CSB-YP865195HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人LRP1B重组蛋白
  • 货号：
    CSB-EP865195HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人LRP1B重组蛋白
  • 货号：
    CSB-EP865195HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人LRP1B重组蛋白
  • 货号：
    CSB-BP865195HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人LRP1B重组蛋白
  • 货号：
    CSB-MP865195HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    LRP1B
  • Uniprot No.：
    Q9NZR2
  • 别名：
    LRP1B; LRPDIT; Low-density lipoprotein receptor-related protein 1B; LRP-1B; Low-density lipoprotein receptor-related protein-deleted in tumor; LRP-DIT
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis.
  • 基因功能参考文献：
    1. LRP1B mutations are highly prevalent among the lung adenocarcinoma patients with COPD. PMID: 28522810
    2. Data show that overexpression of full-length mouse Lrp1b leads to impaired cellular proliferation, while humsn LRP1B knockdown has the opposite effect. PMID: 27626682
    3. that LRP1B interacted with DVL2, inhibited the interaction between DVL2 and Axin, and negatively regulated beta-catenin/TCF signaling PMID: 28408316
    4. LRP1B gene is a target for human papillomavirus integrations and chromosome rearrangements in oropharyngeal squamous cell carcinoma. PMID: 27636103
    5. LRP1B, BRD2 and CACNA1D are new candidate genes in fetal metabolic programming of newborns exposed to maternal hyperglycemia. PMID: 26586120
    6. LRP1B presents with frequent molecular alterations for glioblastoma patients; its deletion may impact patient outcome. PMID: 26428308
    7. Silencing of LRP1B altered the expression of focal adhesion complex-associated proteins, and Cdc42/RhoA activities. PMID: 23521319
    8. genetic association studies in Danish population: Quantitative metabolic phenotypes in obesity are associated with SNP in various genes: LRP1B (rs2890652) is associated with body mass index and insulin resistance. PMID: 21953277
    9. LRP1b shows restricted expression in human tissues and binds to several extracellular ligands, including fibrinogen and apoE--carrying lipoproteins PMID: 21420681
    10. Epigenomics and microRNAs inactivate LRP1B, a modulator of the extracellular environment of thyroid cancer cells, and it is deleted in neoplasms. PMID: 21057533
    11. LRP1B was hypermethylated in four gastric cancer cell lines, and low LRP1B mRNA expression was associated with high methylation levels in gastric cancer cell lines. PMID: 20095042
    12. results suggest that haplotypes in the gene LRP1B are significant/protective for successful aging without cognitive decline PMID: 19367585
    13. The LRP1B gene is a candidate tumor suppressor gene in urothelial cancer. PMID: 12004004
    14. LRP1B can function as a negative regulator of uPAR regeneration and cell migration. PMID: 12194987
    15. These findings reveal that low density lipoprotein receptor-related protein 1B is a novel binding partner of beta-amyloid precursor protein (APP) that functions to decrease APP processing to amyloid beta peptides. PMID: 15126508
    16. LRP1B modulates the catabolism of uPAR and PDGFR, affecting the migration of smooth muscle cells. PMID: 15166012
    17. Loss of LRP1B function in esophageal carcinogenesis most often occurs either by homozygous deletion or by transcriptional silencing through hypermethylation of its CpG island. PMID: 15172977
    18. Although mouse LRP1B expresses in the forms of both full-length receptor tail and an alternatively spliced form lacking a 33-amino acid insert, human LRP1B is expressed exclusively in the form of full-length receptor tail PMID: 15963947
    19. LRP1B functions as a receptor for Pseudomonas exotoxin. PMID: 16095885
    20. Frequent inactivation of LRP1B mainly occurs by means of epigenetic mechanisms in oral squamous cell carcinoma, which might play an important role in oral tumorigenesis. PMID: 16918994
    21. LRP1B has tumor suppression function that is mediated by proteolytic processing of the receptor resulting in intracellular domain release. PMID: 17227771

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    LDLR family
  • 组织特异性：
    Expressed in thyroid gland and in salivary gland, as well as in adult and fetal brain.
  • 数据库链接：

    HGNC: 6693

    OMIM: 608766

    KEGG: hsa:53353

    STRING: 9606.ENSP00000374135

    UniGene: Hs.656461

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