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  4. Recombinant Human Leucine-rich repeat-containing protein 7 (LRRC7), partial

Recombinant Human Leucine-rich repeat-containing protein 7 (LRRC7), partial

  • 中文名称：
    人LRRC7重组蛋白
  • 货号：
    CSB-YP853474HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人LRRC7重组蛋白
  • 货号：
    CSB-EP853474HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人LRRC7重组蛋白
  • 货号：
    CSB-EP853474HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人LRRC7重组蛋白
  • 货号：
    CSB-BP853474HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人LRRC7重组蛋白
  • 货号：
    CSB-MP853474HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    LRRC7
  • Uniprot No.：
    Q96NW7
  • 别名：
    Densin 180; Densin; Densin-180; densin180; DKFZp686I1147; KIAA1365; Lamin associated polypeptide 1; LAP 1; Leucine rich repeat containing 7; Leucine rich repeat containing protein 7; Leucine-rich repeat-containing protein 7; Lrrc 7 ; LRRC7; LRRC7_HUMAN; MGC144918; OTTHUMP00000065336; OTTHUMP00000065337; OTTHUMP00000065338; Protein Lap 1; Protein lap1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression.
  • 基因功能参考文献：
    1. The important role of this gene in the synapse and mental illness endophenotypes observed in animal models suggests that LRRC7 may play a role in susceptibility to bipolar disorder. PMID: 26901794
    2. Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylation. PMID: 21610080
    3. We found no genome-wide statistically significant associations but identified several plausible candidate genes among findings at p < 5E-05: LRRC7, TMEM132D, SEMA3A, ALK, and STIP1. PMID: 21784300
    4. Densin-180 co-localized with delta-catenin/NPRAP at synapses in delta-catenin/NPRAP and may be involved in organization of the synaptic cell-cell junction through interaction with the delta-catenin/NPRAP-N-cadherin complex PMID: 11729199
    5. A novel splice variant, LRRC7, of densin-180 is located on 1p31 and consists of 8 exons. Unlike wild type, not brain-specific. PMID: 12525888
    6. expressed by glomerular podocytes and has a role in associating with the nephrin interacting protein complex at the slit diaphragm PMID: 12819232
    7. Densin can act as autoantigen, and autoantibodies against these can be detected in patients with type 1 diabetes. PMID: 16741999
    8. Densin is a novel testicular protein expressed in the cell membranes of Sertoli cells. PMID: 17039495
    9. Densin may associate with the cadherin-catenin and nephrin complex(es), and may be involved in the formation of the cell-cell contacts. PMID: 17581699

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  • 亚细胞定位：
    Cytoplasm. Cell junction, synapse, postsynaptic density.
  • 蛋白家族：
    LAP (LRR and PDZ) protein family
  • 组织特异性：
    Brain-specific. Isoform 3 is ubiquitously expressed.
  • 数据库链接：

    HGNC: 18531

    OMIM: 614453

    KEGG: hsa:57554

    STRING: 9606.ENSP00000035383

    UniGene: Hs.479658

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