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  4. Recombinant Human Leucine-rich repeat-containing protein 16A (LRRC16A), partial

Recombinant Human Leucine-rich repeat-containing protein 16A (LRRC16A), partial

  • 中文名称：
    Recombinant Human Leucine-rich repeat-containing protein 16A(LRRC16A) ,partial
  • 货号：
    CSB-YP713356HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Leucine-rich repeat-containing protein 16A(LRRC16A) ,partial
  • 货号：
    CSB-EP713356HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Leucine-rich repeat-containing protein 16A(LRRC16A) ,partial
  • 货号：
    CSB-EP713356HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Leucine-rich repeat-containing protein 16A(LRRC16A) ,partial
  • 货号：
    CSB-BP713356HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Leucine-rich repeat-containing protein 16A(LRRC16A) ,partial
  • 货号：
    CSB-MP713356HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CARMIL1
  • Uniprot No.：
    Q5VZK9
  • 别名：
    Acan 125; Capping protein; Arp2/3; and myosin I linker; CARMIL homolog; leucine rich repeat containing 16; Leucine-rich repeat-containing protein 16A; LR16A_HUMAN; Lrrc16 protein; LRRC16A; p116
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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CARMIL1 antibodies

靶点详情

  • 功能：
    Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments. Plays a role in lamellipodial protrusion formations and cell migration.
  • 基因功能参考文献：
    1. A novel genetic variant in leucine-rich repeat-containing 16A (LRRC16A) has been associated with reduced ARDS risk. PMID: 27768389
    2. LRRC16A plays a role in adult respiratory distress syndrome pathophysiology by interacting with, and being mediated through, platelets. PMID: 25254322
    3. shown for the first time that CARMIL/LRRC16A was associated with gout, which could be due to urate transportsome failure PMID: 24318514
    4. The results also suggest that the ability of CARMIL1 to inhibit CP in cells may be regulated. PMID: 23904264
    5. Data suggest that CARMIL promotes uncapping by binding to a freely accessible site on Capping protein (CP) bound to a filament barbed end and inducing a change in the conformation of the actin-binding surface of CP. PMID: 22411988
    6. The two CARMIL isoforms are both important for cell migration, but they have distinct functions.[CARMIL1, CARMIL2] PMID: 19846667

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane. Cell projection, lamellipodium.
  • 蛋白家族：
    CARMIL family
  • 组织特异性：
    Expressed in lung, placenta, small intestine, liver, thymus, colon, skeletal muscle, heart and brain. Higher expression in kidney.
  • 数据库链接：

    HGNC: 21581

    OMIM: 609593

    KEGG: hsa:55604

    STRING: 9606.ENSP00000331983

    UniGene: Hs.649550

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