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  4. Recombinant Human Laminin subunit alpha-3 (LAMA3), partial

Recombinant Human Laminin subunit alpha-3 (LAMA3), partial

  • 中文名称：
    人LAMA3重组蛋白
  • 货号：
    CSB-YP623096HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人LAMA3重组蛋白
  • 货号：
    CSB-EP623096HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人LAMA3重组蛋白
  • 货号：
    CSB-EP623096HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人LAMA3重组蛋白
  • 货号：
    CSB-BP623096HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人LAMA3重组蛋白
  • 货号：
    CSB-MP623096HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    LAMA3
  • Uniprot No.：
    Q16787
  • 别名：
    E170; Epiligrin 170 kDa subunit; Epiligrin subunit alpha; Kalinin B1 chain; Kalinin subunit alpha; LAMA3; LAMA3_HUMAN; LAMB3; LAMC2; Laminin gamma 2; Laminin 5 beta 3; Laminin 5 gamma 2 subunit; Laminin beta 3; Laminin subunit alpha-3; Laminin subunit beta 3; Laminin subunit gamma 2; Laminin-5 subunit alpha; Laminin-6 subunit alpha; Laminin-7 subunit alpha; Nicein subunit alpha
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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靶点详情

  • 功能：
    Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.; Laminin-5 is thought to be involved in (1) cell adhesion via integrin alpha-3/beta-1 in focal adhesion and integrin alpha-6/beta-4 in hemidesmosomes, (2) signal transduction via tyrosine phosphorylation of pp125-FAK and p80, (3) differentiation of keratinocytes.
  • 基因功能参考文献：
    1. The study has identified two mutations in two large consanguineous pedigrees. Identification of novel variants in the LAMA3 and PLEC genes will expand the mutation spectrum and also help in genetic counselling of patients in the Pakistani population. PMID: 29797489
    2. Seventeen percent of the patients were compound heterozygous or homozygous for mutations in the gene LAMA3, 59% carried mutations in both alleles of LAMB3, and 12% were homozygous for mutations in LAMC2. In nine patients with severe generalized JEB, detection of two mutations in one of the genes LAMA3, LAMB3, or LAMC2 was not possible, so the molecular basis of disease could not be clarified completely PMID: 27375110
    3. Both parents had offspring affected with JEB and displayed subtle enamel pitting of secondary dentition without any sign of skin blistering. The reported enamel abnormality in LAMA3 mutation carriers could be attributed to a half dose effect of the laminin a3 chain PMID: 27827380
    4. Loss of the normal basement membrane organization of alpha3 laminin observed in fibrotic regions from the lungs of patients with pulmonary fibrosis contributes to their disease progression. PMID: 25188360
    5. Two of the six genes (LAMA3 and DST) validated by quantitative RT-PCR for tumor-specific alternative splicing events PMID: 24675808
    6. LAMNA variants have been identified in atrial fibrillation cohort studies, demonstrating abnormalities in cardiac excitation - supra ventricular tachycardia and atrial fibrillation. PMID: 25443231
    7. We established the LAMA3 gene as novel potential susceptibility gene for atopic dermatitis. PMID: 25363238
    8. Expression of a3, beta3 and beta2 cannot predict the prognosis. However, high expression of beta2 mRNA in HCC/non-cancerous liver correlated significantly with the absence of complete encapsulation, which is an important tumor invasiveness factor. PMID: 21940345
    9. Results describe a new pedigree identifying a novel mutation of LAMA3 in LOC syndrome PMID: 23869449
    10. A male patient with Herlitz junctional epidermolysis bullosa with a novel homozygosity for insertion LAMA3 Premature Termination Codon mutation is described. Both parents and his sibling were shown to be heterozygous carriers. PMID: 22963541
    11. High LAMA3 expression is associated with gastric cancer. PMID: 23907728
    12. proteolytic processing of laminin-5 influences its interaction with alpha3beta1 integrin PMID: 14612440
    13. The uncoordinated production of chains of ln-5 in allergic asthma could have a bearing on the poor epithelial cell anchorage in these patients. PMID: 16179086
    14. tumor cell migration on laminin-5 is inhibited by HYD1, a biologically active integrin-targeting peptide PMID: 16537560
    15. Laminin-5 alone stimulates global changes in gene/protein expression in mesenchymal stem cells that lead to commitment of these cells to the osteogenic phenotype, and this correlates with extracellular matrix production. PMID: 17137774
    16. LM-332 is a crucial motility-promoting factor for B-CLL lymphocytes and is a potential constituent favoring the dissemination of B-CLL lymphocytes through vascular basement membranes and possibly lymph node compartments. PMID: 17482449
    17. The major contributions of laminin-5 to the resistance of the epidermis against frictional stress but also for basement membrane regeneration and repair of damaged skin are reflected by the phenotype of Herlitz junctional epidermolysis bullosa. PMID: 17000025
    18. Letter/Case Report: report novel LAMA3 mutations leading to enamel defects in epidermolysis bullosa. PMID: 22434185
    19. Data show laminin-332 (alpha3ss3gamma2)(Lm332) matrix supported adhesion of keratinocytes much more strongly and stably than purified Lm332. PMID: 22563463
    20. results suggest that Lm3B11/3B21 may be required for normal mature vessels and interfere with tumor angiogenesis PMID: 21276136
    21. the LAMA3 LG45 domain may trigger different signals toward keratinocytes depending on its interaction with syndecan-1 or -4. PMID: 22351752
    22. Cell surface COL17 can interact with laminin 332 and, together, participate in the adherence of a cell to the extracellular matrix. PMID: 21034821
    23. SEMA3F, CLEC16A, LAMA3, and PCSK2 variants have roles in myocardial infarction in Japanese individuals PMID: 20036365
    24. Bisecting GlcNAc residues on laminin-332 down-regulate galectin-3-dependent keratinocyte motility. PMID: 19940114
    25. the alpha3 subunit of laminins-332, -321, and -311 plays an important role in mediating epidermal-dermal integrity and is essential for the skin to withstand mechanical stresses PMID: 19945619
    26. a hypoxia related splice variant of LAMA3 may have a role in progression of head and neck cancers PMID: 19936049
    27. Characterization of morphological and cytoskeletal changes in MCF10A breast epithelial cells plated on laminin-5: comparison with breast cancer cell line MCF7. PMID: 11775027
    28. Neurite outgrowth promoting sites have been identified on the laminin alpha 3 chain LG4 module. PMID: 12196012
    29. In all developing organs investigated, the mRNA of the alpha3 chain of laminin is strictly of epithelial origin and the corresponding protein localised in the underlying basement membrane zones PMID: 12382139
    30. These results suggest that the G3 domain of laminin 5 alpha 3 contains two distinct regions that differently regulate cell adhesion and migration. PMID: 12532327
    31. laminin alpha 3 LG4 module may play an important role in tissue remodeling by inducing MMP-1 expression during wound healing PMID: 12826666
    32. a missense mutation in the adhesion G domain of laminin-5 causes mild junctional epidermolysis bullosa PMID: 12943669
    33. results demonstrate that the laminin alpha3 LG4/5 modules within unprocessed laminin-5 permit its cell binding activity through heparan and chondroitin sulfate chains of syndecan-1 PMID: 12947106
    34. LAMA3 promoter methylation is associated with increased breast tumor stage and tumor size PMID: 14695139
    35. Characterization of laminin 5B and NH2-terminal proteolytic fragment of its alpha3B chain PMID: 15044476
    36. co-cultures of epithelial cells and fibroblasts were studied to analyse the processing of laminin 5 alpha3, beta3, and gamma2 chains PMID: 15149852
    37. The G4/5 domain in the alpha3 chain facilitates deposition of precursor laminin 5 into the PBM in epidermal wounds PMID: 15316072
    38. Premature termination codon mutations in both alleles of LAMB3 or LAMC2 genes were found in nine of the 11 H junctional epidermolysis bullosa patients PMID: 15373767
    39. the LG4-5 domain synergistically enhances integrin signaling as it is released from the precursor LN5 PMID: 15695818
    40. the absolute mRNA levels generated from the laminin 5 genes do not determine the translated protein levels of the laminin 5 chains in keratinocytes; the expression of the laminin 5 genes may be controlled by common regulation mechanisms PMID: 15854126
    41. Suppression of laminin-5 alpha 3-chain expression in human mammary epithelial cells results in loss of reconstituted extracellular matrix-mediated growth control and apoptosis. PMID: 16219677
    42. The hinge region between subdomains G3 and G4 of laminin alpha 3 carries the proteolytic cleavage sites but proteolytic processing plays no role in kerocyte migration. PMID: 16297184
    43. Laminin-5 may contribute to the development of bone tissues by promoting the proliferation and by suppressing the chondrogenic differentiation of MSCs. PMID: 17071854
    44. These results suggest a new possible approach to repairing SCI and, in general, a model which will be useful for other multidisciplinary procedures for complex neurological situations. PMID: 17466943
    45. These results suggest that Crk is required for early attachment to laminin, cell motility, and growth of glioblastoma cell line KMG4. PMID: 17825249
    46. the alpha3 chain can assemble with only beta3-gamma2 heterodimer to form a heterotrimer via disulfide bonds PMID: 18603785
    47. Alpha3- and alpha5-laminins, but not other laminin isoforms, mediate mast cell adhesion via alpha3beta1 integrin. PMID: 19752234
    48. immunofluorescence analyses revealed a basement membrane staining in epithelial tissue for LaNt alpha3 and LaNt alpha3 localized along the substratum-associated surface of cultured keratinocytes. PMID: 19773554

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  • 相关疾病：
    Epidermolysis bullosa, junctional, Herlitz type (H-JEB); Laryngoonychocutaneous syndrome (LOCS)
  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.
  • 组织特异性：
    Skin; respiratory, urinary, and digestive epithelia and in other specialized tissues with prominent secretory or protective functions. Epithelial basement membrane, and epithelial cell tongue that migrates into a wound bed. A differential and focal expres
  • 数据库链接：

    HGNC: 6483

    OMIM: 226700

    KEGG: hsa:3909

    STRING: 9606.ENSP00000324532

    UniGene: Hs.436367

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