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  4. Recombinant Human Kinesin-like protein KIF24 (KIF24), partial

Recombinant Human Kinesin-like protein KIF24 (KIF24), partial

  • 中文名称：
    人KIF24重组蛋白
  • 货号：
    CSB-YP716354HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人KIF24重组蛋白
  • 货号：
    CSB-EP716354HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人KIF24重组蛋白
  • 货号：
    CSB-EP716354HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人KIF24重组蛋白
  • 货号：
    CSB-BP716354HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人KIF24重组蛋白
  • 货号：
    CSB-MP716354HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    KIF24
  • Uniprot No.：
    Q5T7B8
  • 别名：
    bA571F15.4; C9orf48; Kif24; KIF24_HUMAN; kinesin family member 24; Kinesin-like protein KIF24; RP11-571F15.7
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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KIF24 antibodies

靶点详情

  • 功能：
    Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation. Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle.
  • 基因功能参考文献：
    1. Kif24 is a physiological substrate of Nek2, which regulates cilia disassembly through a concerted mechanism involving Kif24-mediated microtubule depolymerization. PMID: 26290419
    2. Study found that loss of Kif24 leads to the disappearance of CP110 from mother centrioles in cycling cells able to form cilia; thus, identifying a centriolar kinesin that specifically remodels a subset of microtubules, thereby regulating cilia assembly. PMID: 21620453
    3. KIF24 rs17350674 polymorphism likely acts as a risk factor for sporadic Lobar Degeneration PMID: 20670673
    4. Observational study of gene-disease association. (HuGE Navigator) PMID: 20670673
  • 亚细胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Primarily localizes to the mother centriole/basal body and is either absent at daughter centriole.
  • 蛋白家族：
    TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family
  • 数据库链接：

    HGNC: 19916

    OMIM: 613747

    KEGG: hsa:347240

    STRING: 9606.ENSP00000368464

    UniGene: Hs.710246

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